{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen Q"],"funding":["2020 Natural Science Foundation of Fujian Province"],"pagination":["877-888"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11290754"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["19(10)"],"pubmed_abstract":["<b>Aim:</b> This study aims to explore the molecular mechanisms of cystic fibrosis (CF) complicated with nontuberculous mycobacteria (NTM) infection. <b>Materials & methods:</b> Expression profiles of CF with NTM-infected patients were downloaded from GEO database. Intersection analysis yielded 78 genes associated with CF with NTM infection. The protein-protein interaction (PPI) network and the functions of hub genes were investigated. <b>Results:</b> Five hub genes (<i>PIK3R1</i>, <i>IL1A</i>, <i>CXCR4</i>, <i>ACTN1</i>, <i>PFN1</i>) were identified, which were primarily enriched in actin-related biological processes and pathways. Transcription factors <i>RELA</i>, <i>JUN</i>, <i>NFKB1</i> and <i>FOS</i> that regulated hub genes modulated <i>IL1A</i> expression, while 21 other transcripti"],"journal":["Future microbiology"],"pubmed_title":["Molecular mechanism analysis of nontuberculous mycobacteria infection in patients with cystic fibrosis."],"pmcid":["PMC11290754"],"funding_grant_id":["2020J011146"],"pubmed_authors":["Chen Q","Li J"],"additional_accession":[]},"is_claimable":false,"name":"Molecular mechanism analysis of nontuberculous mycobacteria infection in patients with cystic fibrosis.","description":"<b>Aim:</b> This study aims to explore the molecular mechanisms of cystic fibrosis (CF) complicated with nontuberculous mycobacteria (NTM) infection. <b>Materials & methods:</b> Expression profiles of CF with NTM-infected patients were downloaded from GEO database. Intersection analysis yielded 78 genes associated with CF with NTM infection. The protein-protein interaction (PPI) network and the functions of hub genes were investigated. <b>Results:</b> Five hub genes (<i>PIK3R1</i>, <i>IL1A</i>, <i>CXCR4</i>, <i>ACTN1</i>, <i>PFN1</i>) were identified, which were primarily enriched in actin-related biological processes and pathways. Transcription factors <i>RELA</i>, <i>JUN</i>, <i>NFKB1</i> and <i>FOS</i> that regulated hub genes modulated <i>IL1A</i> expression, while 21 other transcripti","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-05-25T03:09:41.047Z","creation":"2025-07-08T03:13:44.143Z"},"accession":"S-EPMC11290754","cross_references":{"pubmed":["38700285"],"doi":["10.2217/fmb-2023-0237"]}}