biostudies-literatureUnknown79(8)Ergun MPfizer<h4>Background</h4>Isavuconazole is a relatively new antifungal agent indicated for the management of various invasive fungal diseases (IFDs), including invasive aspergillosis. Information on real-world experience with isavuconazole is scarce. This retrospective observational study aimed to describe the usage of isavuconazole in clinical practice with an in-depth evaluation of individual isavuconazole exposure.<h4>Methods</h4>Patients treated with isavuconazole were evaluated based on retrospective data, including therapeutic drug monitoring (TDM) data and efficacy and safety data. Additionally, we calculated the individual isavuconazole exposure described by the average AUC24 over the first 7 days of treatment by means of non-linear mixed-effects modelling and compared this with the curreThe Journal of antimicrobial chemotherapy1801-1810https://www.ebi.ac.uk/biostudies/studies/S-EPMC11290874biostudies-literatureIsavuconazole as prophylaxis and therapy for invasive fungal diseases: a real-life observational study.PMC11290874Hilbrands LBSchouten JAJansen AMEKunst HReijers MHEErgun MVerweij PEde Kort EBruggemann RJMfalseIsavuconazole as prophylaxis and therapy for invasive fungal diseases: a real-life observational study.<h4>Background</h4>Isavuconazole is a relatively new antifungal agent indicated for the management of various invasive fungal diseases (IFDs), including invasive aspergillosis. Information on real-world experience with isavuconazole is scarce. This retrospective observational study aimed to describe the usage of isavuconazole in clinical practice with an in-depth evaluation of individual isavuconazole exposure.<h4>Methods</h4>Patients treated with isavuconazole were evaluated based on retrospective data, including therapeutic drug monitoring (TDM) data and efficacy and safety data. Additionally, we calculated the individual isavuconazole exposure described by the average AUC24 over the first 7 days of treatment by means of non-linear mixed-effects modelling and compared this with the curre2024-01-01T00:00:00Z2024 Aug2026-03-16T05:42:18.301Z2025-08-14T03:06:14.199ZS-EPMC112908743893589310.1093/jac/dkae139