biostudies-literatureUnknownFazzari ENIMH NIH HHSNHGRI NIH HHSNCI NIH HHSNIGMS NIH HHSGlioblastoma (GBM) is the deadliest form of primary brain tumor with limited treatment options. Recent studies have profiled GBM tumor heterogeneity, revealing numerous axes of variation that explain the molecular and spatial features of the tumor. Here, we seek to bridge descriptive characterization of GBM cell type heterogeneity with the functional role of individual populations within the tumor. Our lens leverages a gene program-centric meta-atlas of published transcriptomic studies to identify commonalities between diverse tumors and cell types in order to decipher the mechanisms that drive them. This approach led to the discovery of a tumor-derived stem cell population with mixed vascular and neural stem cell features, termed a neurovascular progenitor (NVP). Following <i>in situ</i> bioRxiv : the preprint server for biology2024.07.24.604840https://www.ebi.ac.uk/biostudies/studies/S-EPMC11291138biostudies-literatureGlioblastoma Neurovascular Progenitor Orchestrates Tumor Cell Type Diversity.PMC11291138U24 HG002371T32 GM008042R01 CA251221T32 GM152342P50 CA211015RF1 MH132662Haka VCadet DBhaduri ANano PRLiau LMSoto JAKan RLAzizad DJCrouch EEYu KPerryman TLi MXPatel KSGe WTum HABayley NAWick BNathanson DADeneen BTse CRaleigh DRFazzari EfalseGlioblastoma Neurovascular Progenitor Orchestrates Tumor Cell Type Diversity.Glioblastoma (GBM) is the deadliest form of primary brain tumor with limited treatment options. Recent studies have profiled GBM tumor heterogeneity, revealing numerous axes of variation that explain the molecular and spatial features of the tumor. Here, we seek to bridge descriptive characterization of GBM cell type heterogeneity with the functional role of individual populations within the tumor. Our lens leverages a gene program-centric meta-atlas of published transcriptomic studies to identify commonalities between diverse tumors and cell types in order to decipher the mechanisms that drive them. This approach led to the discovery of a tumor-derived stem cell population with mixed vascular and neural stem cell features, termed a neurovascular progenitor (NVP). Following <i>in situ</i> 2024-01-01T00:00:00Z2024 Jul2026-06-03T03:13:08.046Z2024-11-20T12:36:36.337ZS-EPMC112911383909187710.1101/2024.07.24.604840