{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Mrabti C"],"funding":["Intramural NIH HHS"],"pubmed_abstract":["Aging is the major risk factor for most human diseases and represents a major socio-economical challenge for modern societies. Despite its importance, the process of aging remains poorly understood. Epigenetic dysregulation has been proposed as a key driver of the aging process. Modifications in transcriptional networks and chromatin structure might be central to age-related functional decline. A prevalent feature described during aging is the overall reduction in heterochromatin, specifically marked by the loss of repressive histone modification, Histone 3 lysine 9 trimethylation (H3K9me3). However, the role of H3K9me3 in aging, especially in mammals, remains unclear. Here we show using a novel mouse strain, (TKOc), carrying a triple knockout of three methyltransferases responsible for H3"],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.07.24.604929"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11291141"],"repository":["biostudies-literature"],"pubmed_title":["Loss of H3K9 trimethylation leads to premature aging."],"pmcid":["PMC11291141"],"funding_grant_id":["ZIA AG000679"],"pubmed_authors":["von Meyenn F","Ocampo A","Alonso-Calleja A","Pico S","Naveiras O","Yang N","Branchina C","Schoenfeldt L","Horvath S","Sen P","Brooke R","Desdin-Mico G","Parras A","Haghani A","Maroun CY","Piao Y","Del Carmen Maza M","Mrabti C","Vilchez-Acosta A","Luo S"],"additional_accession":[]},"is_claimable":false,"name":"Loss of H3K9 trimethylation leads to premature aging.","description":"Aging is the major risk factor for most human diseases and represents a major socio-economical challenge for modern societies. Despite its importance, the process of aging remains poorly understood. Epigenetic dysregulation has been proposed as a key driver of the aging process. Modifications in transcriptional networks and chromatin structure might be central to age-related functional decline. A prevalent feature described during aging is the overall reduction in heterochromatin, specifically marked by the loss of repressive histone modification, Histone 3 lysine 9 trimethylation (H3K9me3). However, the role of H3K9me3 in aging, especially in mammals, remains unclear. Here we show using a novel mouse strain, (TKOc), carrying a triple knockout of three methyltransferases responsible for H3","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-06T19:28:59.4Z","creation":"2025-04-06T19:28:59.4Z"},"accession":"S-EPMC11291141","cross_references":{"pubmed":["39091811"],"doi":["10.1101/2024.07.24.604929"]}}