{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee J"],"funding":["National Research Foundation of Korea"],"pagination":["17632"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11292015"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(1)"],"pubmed_abstract":["Structural failure is a well-established complication of rotator cuff repair procedures. To evaluate the effect of magnetic microbeads, designed for precise drug delivery via magnetic force, on sustained transforming growth factor-beta-1 (TGF-β1) release and rotator cuff healing in a rat rotator cuff repair model. TGF-β1 laden microbeads were prepared, and baseline in vitro experiments included the magnetization of the microbeads and TGF-β1 release tests. In an in vivo experiment using a rat rotator cuff repair model on both shoulders, 72 rats were randomly assigned to three groups (24 per group): group A, conventional repair; group B, repair with and simple TGF-β1 injection; and group C, repair with magnet insertion into the humeral head and TGF-β1 laden microbead injection. Delivery of T"],"journal":["Scientific reports"],"pubmed_title":["Effect of magnetic microbeads on sustained and targeted delivery of transforming growth factor-beta-1 for rotator cuff healing in a rat rotator cuff repair model."],"pmcid":["PMC11292015"],"funding_grant_id":["RS-2023-00249219","NRF-2022R1A6A3A01087378"],"pubmed_authors":["Chung SW","Yoon JP","Park J","Lee J","Chang Y"],"additional_accession":[]},"is_claimable":false,"name":"Effect of magnetic microbeads on sustained and targeted delivery of transforming growth factor-beta-1 for rotator cuff healing in a rat rotator cuff repair model.","description":"Structural failure is a well-established complication of rotator cuff repair procedures. To evaluate the effect of magnetic microbeads, designed for precise drug delivery via magnetic force, on sustained transforming growth factor-beta-1 (TGF-β1) release and rotator cuff healing in a rat rotator cuff repair model. TGF-β1 laden microbeads were prepared, and baseline in vitro experiments included the magnetization of the microbeads and TGF-β1 release tests. In an in vivo experiment using a rat rotator cuff repair model on both shoulders, 72 rats were randomly assigned to three groups (24 per group): group A, conventional repair; group B, repair with and simple TGF-β1 injection; and group C, repair with magnet insertion into the humeral head and TGF-β1 laden microbead injection. Delivery of T","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-18T20:23:09.769Z","creation":"2025-02-19T02:27:41.682Z"},"accession":"S-EPMC11292015","cross_references":{"pubmed":["39085278"],"doi":["10.1038/s41598-024-67572-y"]}}