{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["56(3)"],"submitter":["Li Y"],"pubmed_abstract":["Psoriasis is accepted as a chronic, inflammatory, immune-mediated skin disease triggered by complex environmental and genetic factors. For a long time, disease recurrence, drug rejection, and high treatment costs have remained enormous challenges and burdens to patients and clinicians. Natural products with effective immunomodulatory and anti-inflammatory activities from medicinal plants have the potential to combat psoriasis and complications. Herein, an imiquimod (IMQ)-induced psoriasis-like dermatitis model is established in mice. The model mice are treated with 1% rutaecarpine (RUT) (external use) or the oral administration of RUT at different concentrations. Furthermore, high-throughput 16S rRNA gene sequencing is applied to analyze the changes in the diversity and composition of the "],"journal":["Acta biochimica et biophysica Sinica"],"pagination":["345-355"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11292129"],"repository":["biostudies-literature"],"pubmed_title":["Rutaecarpine ameliorates imiquimod-induced psoriasis-like dermatitis in mice associated with alterations in the gut microbiota."],"pmcid":["PMC11292129"],"pubmed_authors":["Li W","Zhang G","Li Y","Li Z","Tan Z"],"additional_accession":[]},"is_claimable":false,"name":"Rutaecarpine ameliorates imiquimod-induced psoriasis-like dermatitis in mice associated with alterations in the gut microbiota.","description":"Psoriasis is accepted as a chronic, inflammatory, immune-mediated skin disease triggered by complex environmental and genetic factors. For a long time, disease recurrence, drug rejection, and high treatment costs have remained enormous challenges and burdens to patients and clinicians. Natural products with effective immunomodulatory and anti-inflammatory activities from medicinal plants have the potential to combat psoriasis and complications. Herein, an imiquimod (IMQ)-induced psoriasis-like dermatitis model is established in mice. The model mice are treated with 1% rutaecarpine (RUT) (external use) or the oral administration of RUT at different concentrations. Furthermore, high-throughput 16S rRNA gene sequencing is applied to analyze the changes in the diversity and composition of the ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Mar","modification":"2026-05-02T12:47:00.51Z","creation":"2025-02-19T02:27:45.357Z"},"accession":"S-EPMC11292129","cross_references":{"pubmed":["38419497"],"doi":["10.3724/abbs.2024018"]}}