biostudies-literatureLavin Flores ANIGMS NIH HHS32980-32990https://www.ebi.ac.uk/biostudies/studies/S-EPMC11292628biostudies-literatureUnknown9(30)Iron oxide nanoparticles (IONPs) are recognized for their potential in biomedical applications due to their distinctive physicochemical properties. This study investigates the synthesis of IONPs with various geometric morphologies-cubic, star-like, truncated icosahedron, and spherical-via thermal decomposition to enhance their utility in magnetic resonance imaging (MRI) and targeted drug delivery. X-ray diffraction analysis verified the Fe₃O₄ phase in all nanoparticles, illustrating the synthesis's efficacy. Particle morphologies were well-defined, with sizes ranging from 10 to 150 nm, as determined by transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Magnetic evaluations using a vibrating sample magnetometer (VSM-PPMs) demonstrated their ACS omegaGeometry and Surface Area Optimization in Iron Oxide Nanoparticles for Enhanced Magnetic Properties.PMC11292628R25 GM061151Morell GPantoja-Romero WMedina-Berrios NBerrios Plaza DKisslinger KLavin Flores ABeltran-Huarac JWeiner BRfalseGeometry and Surface Area Optimization in Iron Oxide Nanoparticles for Enhanced Magnetic Properties.Iron oxide nanoparticles (IONPs) are recognized for their potential in biomedical applications due to their distinctive physicochemical properties. This study investigates the synthesis of IONPs with various geometric morphologies-cubic, star-like, truncated icosahedron, and spherical-via thermal decomposition to enhance their utility in magnetic resonance imaging (MRI) and targeted drug delivery. X-ray diffraction analysis verified the Fe₃O₄ phase in all nanoparticles, illustrating the synthesis's efficacy. Particle morphologies were well-defined, with sizes ranging from 10 to 150 nm, as determined by transmission electron microscopy (TEM) and scanning electron microscopy (SEM). Magnetic evaluations using a vibrating sample magnetometer (VSM-PPMs) demonstrated their 2024-01-01T00:00:00Z2024 Jul2025-04-04T00:08:29.962Z2025-02-19T02:27:26.866ZS-EPMC112926283910035610.1021/acsomega.4c03988