biostudies-literatureCook LParkinson's FoundationNIA NIH HHSNINDS NIH HHSParkinson’s Foundation2668-2679https://www.ebi.ac.uk/biostudies/studies/S-EPMC11292896biostudies-literatureUnknown147(8)Variants in seven genes (LRRK2, GBA1, PRKN, SNCA, PINK1, PARK7 and VPS35) have been formally adjudicated as causal contributors to Parkinson's disease; however, individuals with Parkinson's disease are often unaware of their genetic status since clinical testing is infrequently offered. As a result, genetic information is not incorporated into clinical care, and variant-targeted precision medicine trials struggle to enrol people with Parkinson's disease. Understanding the yield of genetic testing using an established gene panel in a large, geographically diverse North American population would help patients, clinicians, clinical researchers, laboratories and insurers better understand the importance of genetics in approaching Parkinson's disease. PD GENEration is an ongoing multi-centre, oBrain : a journal of neurologyParkinson's disease variant detection and disclosure: PD GENEration, a North American study.PMC11292896P30 AG066518P30 AG072979K08 NS131581Marder KSSinger CStrom SPCarbonell JRao SCMencacci NEBlauwendraat CWills AMMeng YBressman SAlcalay RNSchwantes-An THLitvan INance MASimuni TCruz Vicioso RKatus LGhosh Galvelis KHall AShill HALohmann KHodges PDForoud TMata IFLyons KEVerbrugge JCook LQuinn JFSchwarzschild MACasaceli CBeck JCNaito ASchulze JFernandez HHTropea TFVanegas Arroyave NfalseParkinson's disease variant detection and disclosure: PD GENEration, a North American study.Variants in seven genes (LRRK2, GBA1, PRKN, SNCA, PINK1, PARK7 and VPS35) have been formally adjudicated as causal contributors to Parkinson's disease; however, individuals with Parkinson's disease are often unaware of their genetic status since clinical testing is infrequently offered. As a result, genetic information is not incorporated into clinical care, and variant-targeted precision medicine trials struggle to enrol people with Parkinson's disease. Understanding the yield of genetic testing using an established gene panel in a large, geographically diverse North American population would help patients, clinicians, clinical researchers, laboratories and insurers better understand the importance of genetics in approaching Parkinson's disease. PD GENEration is an ongoing multi-centre, o2024-01-01T00:00:00Z2024 Aug2026-06-23T03:13:44.078Z2025-02-19T02:27:20.835ZS-EPMC112928963907499210.1093/brain/awae142