biostudies-literatureUnknownWan Z<h4>Background</h4>The literature on the association between fine particulate matter (PM2.5) exposure and gestational diabetes mellitus (GDM) risk has focused mainly on exposure during the first and second trimesters, and the research results are inconsistent. Therefore, this study aimed to investigate the associations between PM2.5 exposure during preconception, the first trimester and second trimester and GDM risk in pregnant women in Guangzhou.<h4>Methods</h4>A retrospective cohort study of 26 354 pregnant women was conducted, estimating PM2.5, particulate matter with a diameter >10 µm (PM10), sulphur dioxide (SO2), carbon monoxide (CO) and ozone (O3) exposure during preconception and the first and second trimesters. Analyses were performed using Cox proportional hazards models and nonlEuropean journal of public healthckae094https://www.ebi.ac.uk/biostudies/studies/S-EPMC11293809biostudies-literatureEffect of fine particulate matter exposure on gestational diabetes mellitus risk: a retrospective cohort study.PMC11293809Lai HQiu CWan ZZhuang GZhang SLiu WfalseEffect of fine particulate matter exposure on gestational diabetes mellitus risk: a retrospective cohort study.<h4>Background</h4>The literature on the association between fine particulate matter (PM2.5) exposure and gestational diabetes mellitus (GDM) risk has focused mainly on exposure during the first and second trimesters, and the research results are inconsistent. Therefore, this study aimed to investigate the associations between PM2.5 exposure during preconception, the first trimester and second trimester and GDM risk in pregnant women in Guangzhou.<h4>Methods</h4>A retrospective cohort study of 26 354 pregnant women was conducted, estimating PM2.5, particulate matter with a diameter >10 µm (PM10), sulphur dioxide (SO2), carbon monoxide (CO) and ozone (O3) exposure during preconception and the first and second trimesters. Analyses were performed using Cox proportional hazards models and nonl2024-01-01T00:00:00Z2024 May2025-04-19T20:46:31.805Z2025-02-19T02:27:34.981ZS-EPMC112938093878360910.1093/eurpub/ckae094