biostudies-literatureKancherla VCenters for Disease Control and PreventionCDC HHSe2370https://www.ebi.ac.uk/biostudies/studies/S-EPMC11295258biostudies-literatureUnknown116(6)<h4>Background</h4>Associations between maternal periconceptional exposure to disinfection by-products (DBPs) in drinking water and neural tube defects (NTDs) in offspring are inconclusive, limited in part by exposure misclassification.<h4>Methods</h4>Maternal interview reports of drinking water sources and consumption from the National Birth Defects Prevention Study were linked with DBP concentrations in public water system monitoring data for case children with an NTD and control children delivered during 2000-2005. DBPs analyzed were total trihalomethanes, the five most common haloacetic acids combined, and individual species. Associations were estimated for all NTDs combined and selected subtypes (spina bifida, anencephaly) with maternal periconceptional exposure to DBPs in public wateBirth defects researchMaternal periconceptional exposure to drinking water disinfection by-products and neural tube defects in offspring.PMC11295258U01DD001223FOA #DD09-001FOA #DD09‐001PA #96043NOFO #DD18‐001U01DD001307FOA #DD13‐003PA #02081NOFO #DD18-001FOA #DD13-003U01DD001035Rhoads AFeldkamp MLRomitti PAConway KMMichalski AShaw GMEvans SPMoore CASuhl JNational Birth Defects Prevention StudyHoyt ATLuben TJLanglois PHKancherla VfalseMaternal periconceptional exposure to drinking water disinfection by-products and neural tube defects in offspring.<h4>Background</h4>Associations between maternal periconceptional exposure to disinfection by-products (DBPs) in drinking water and neural tube defects (NTDs) in offspring are inconclusive, limited in part by exposure misclassification.<h4>Methods</h4>Maternal interview reports of drinking water sources and consumption from the National Birth Defects Prevention Study were linked with DBP concentrations in public water system monitoring data for case children with an NTD and control children delivered during 2000-2005. DBPs analyzed were total trihalomethanes, the five most common haloacetic acids combined, and individual species. Associations were estimated for all NTDs combined and selected subtypes (spina bifida, anencephaly) with maternal periconceptional exposure to DBPs in public wate2024-01-01T00:00:00Z2024 Jun2025-04-19T20:48:58.932Z2025-02-19T02:27:36.113ZS-EPMC112952583888844910.1002/bdr2.2370