{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["40(5)"],"submitter":["Lee SS"],"pubmed_abstract":["<b><i>Purpose:</i></b> To investigate gel stent implantation with and without intraoperative sustained-release mitomycin C (MMC SR) in a rabbit model for gel stent implantation, and to examine aqueous humor outflow (AHO) postimplantation. <b><i>Methods:</i></b> Four groups of rabbits were included. Group 1 was untreated (control). Groups 2, 3, and 4 received the gel stent without MMC, with MMC solution (subconjunctival injection), and with MMC SR (subconjunctival injection), respectively. Intraocular pressure (IOP) and AHO were assessed via tonometry and indocyanine green-based angiography, respectively. The main efficacy measure was change in IOP from baseline. <b><i>Results:</i></b> Following gel stent implantation, Groups 2, 3, and 4 maintained ≥20% IOP reduction (response) for a median"],"journal":["Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics"],"pagination":["297-308"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11296147"],"repository":["biostudies-literature"],"pubmed_title":["Using a Novel, Subconjunctival, Sustained-Release Mitomycin C Formulation in a Rabbit Model of Filtration Surgery with Gel Stent Implantation."],"pmcid":["PMC11296147"],"pubmed_authors":["Csaky KG","Yang L","Orilla W","Almazan A","Lee SS","Nagar S","Robinson MR","Rajagopalan L"],"additional_accession":[]},"is_claimable":false,"name":"Using a Novel, Subconjunctival, Sustained-Release Mitomycin C Formulation in a Rabbit Model of Filtration Surgery with Gel Stent Implantation.","description":"<b><i>Purpose:</i></b> To investigate gel stent implantation with and without intraoperative sustained-release mitomycin C (MMC SR) in a rabbit model for gel stent implantation, and to examine aqueous humor outflow (AHO) postimplantation. <b><i>Methods:</i></b> Four groups of rabbits were included. Group 1 was untreated (control). Groups 2, 3, and 4 received the gel stent without MMC, with MMC solution (subconjunctival injection), and with MMC SR (subconjunctival injection), respectively. Intraocular pressure (IOP) and AHO were assessed via tonometry and indocyanine green-based angiography, respectively. The main efficacy measure was change in IOP from baseline. <b><i>Results:</i></b> Following gel stent implantation, Groups 2, 3, and 4 maintained ≥20% IOP reduction (response) for a median","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jun","modification":"2025-04-26T03:33:10.24Z","creation":"2025-04-06T10:47:09.153Z"},"accession":"S-EPMC11296147","cross_references":{"pubmed":["38687355"],"doi":["10.1089/jop.2023.0100"]}}