biostudies-literatureUnknown40(5)Lee SS<b><i>Purpose:</i></b> To investigate gel stent implantation with and without intraoperative sustained-release mitomycin C (MMC SR) in a rabbit model for gel stent implantation, and to examine aqueous humor outflow (AHO) postimplantation. <b><i>Methods:</i></b> Four groups of rabbits were included. Group 1 was untreated (control). Groups 2, 3, and 4 received the gel stent without MMC, with MMC solution (subconjunctival injection), and with MMC SR (subconjunctival injection), respectively. Intraocular pressure (IOP) and AHO were assessed via tonometry and indocyanine green-based angiography, respectively. The main efficacy measure was change in IOP from baseline. <b><i>Results:</i></b> Following gel stent implantation, Groups 2, 3, and 4 maintained ≥20% IOP reduction (response) for a medianJournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics297-308https://www.ebi.ac.uk/biostudies/studies/S-EPMC11296147biostudies-literatureUsing a Novel, Subconjunctival, Sustained-Release Mitomycin C Formulation in a Rabbit Model of Filtration Surgery with Gel Stent Implantation.PMC11296147Csaky KGYang LOrilla WAlmazan ALee SSNagar SRobinson MRRajagopalan LfalseUsing a Novel, Subconjunctival, Sustained-Release Mitomycin C Formulation in a Rabbit Model of Filtration Surgery with Gel Stent Implantation.<b><i>Purpose:</i></b> To investigate gel stent implantation with and without intraoperative sustained-release mitomycin C (MMC SR) in a rabbit model for gel stent implantation, and to examine aqueous humor outflow (AHO) postimplantation. <b><i>Methods:</i></b> Four groups of rabbits were included. Group 1 was untreated (control). Groups 2, 3, and 4 received the gel stent without MMC, with MMC solution (subconjunctival injection), and with MMC SR (subconjunctival injection), respectively. Intraocular pressure (IOP) and AHO were assessed via tonometry and indocyanine green-based angiography, respectively. The main efficacy measure was change in IOP from baseline. <b><i>Results:</i></b> Following gel stent implantation, Groups 2, 3, and 4 maintained ≥20% IOP reduction (response) for a median2024-01-01T00:00:00Z2024 Jun2025-04-26T03:33:10.24Z2025-04-06T10:47:09.153ZS-EPMC112961473868735510.1089/jop.2023.0100