biostudies-literatureUnknown7(8)Ronellenfitsch U<h4>Importance</h4>The prognosis of patients with adenocarcinoma of the esophagus and esophagogastric junction (AEG) is poor. From current evidence, it remains unclear to what extent preoperative chemoradiotherapy (CRT) or preoperative and/or perioperative chemotherapy achieve better outcomes than surgery alone.<h4>Objective</h4>To assess the association of preoperative CRT and preoperative and/or perioperative chemotherapy in patients with AEG with overall survival and other outcomes.<h4>Data sources</h4>Literature search in PubMed, Cochrane Library, Cumulative Index to Nursing and Allied Health Literature, ClinicalTrials.gov, and International Clinical Trials Registry Platform was performed from inception to April 21, 2023.<h4>Study selection</h4>Two blinded reviewers screened for randomJAMA network opene2425581https://www.ebi.ac.uk/biostudies/studies/S-EPMC11297377biostudies-literaturePreoperative Chemoradiotherapy vs Chemotherapy for Adenocarcinoma of the Esophagogastric Junction: A Network Meta-Analysis.PMC11297377Nilsson MKieser MEyck BMCunningham DShi QVey JALutz MMichl PGrilli MLordick FProctor TVordermark DMichalski CWRonellenfitsch USeide SBarbier ENankivell MHofheinz RDStahl MUrba SBass GALangley RWalsh TNFriedrichs Jvan Lanschot JYchou MKleeff JShah MABurmeister BMauer MKlevebro FfalsePreoperative Chemoradiotherapy vs Chemotherapy for Adenocarcinoma of the Esophagogastric Junction: A Network Meta-Analysis.<h4>Importance</h4>The prognosis of patients with adenocarcinoma of the esophagus and esophagogastric junction (AEG) is poor. From current evidence, it remains unclear to what extent preoperative chemoradiotherapy (CRT) or preoperative and/or perioperative chemotherapy achieve better outcomes than surgery alone.<h4>Objective</h4>To assess the association of preoperative CRT and preoperative and/or perioperative chemotherapy in patients with AEG with overall survival and other outcomes.<h4>Data sources</h4>Literature search in PubMed, Cochrane Library, Cumulative Index to Nursing and Allied Health Literature, ClinicalTrials.gov, and International Clinical Trials Registry Platform was performed from inception to April 21, 2023.<h4>Study selection</h4>Two blinded reviewers screened for random2024-01-01T00:00:00Z2024 Aug2026-06-01T22:18:11.858Z2026-05-22T03:08:00.19ZS-EPMC112973773909356010.1001/jamanetworkopen.2024.25581