biostudies-literatureUnderwood PCNIDDK NIH HHSe2425354https://www.ebi.ac.uk/biostudies/studies/S-EPMC11297381biostudies-literatureUnknown7(8)<h4>Importance</h4>Individuals with diabetes commonly experience Alzheimer disease and related dementias (ADRD). Factors such as hypoglycemia, hyperglycemia, and glycemic variability have been associated with increased risk of ADRD. Traditional glycemic measures, such as mean glycated hemoglobin A1c (HbA1c), may not identify the dynamic and complex pathophysiologic factors in the association between diabetes and ADRD. The HbA1c time in range (TIR) is a previously developed measure of glycemic control that expresses HbA1c stability over time within specific ranges. This measure may inform the current understanding of the association between glucose levels over time and ADRD incidence.<h4>Objective</h4>To examine the association between HbA1c TIR and incidence of ADRD in older veterans with JAMA network openGlycated Hemoglobin A1c Time in Range and Dementia in Older Adults With Diabetes.PMC11297381R01 DK114098Mohr DCPrentice JCBudson AEZhang LNelson REConlin PRUnderwood PCfalseGlycated Hemoglobin A1c Time in Range and Dementia in Older Adults With Diabetes.<h4>Importance</h4>Individuals with diabetes commonly experience Alzheimer disease and related dementias (ADRD). Factors such as hypoglycemia, hyperglycemia, and glycemic variability have been associated with increased risk of ADRD. Traditional glycemic measures, such as mean glycated hemoglobin A1c (HbA1c), may not identify the dynamic and complex pathophysiologic factors in the association between diabetes and ADRD. The HbA1c time in range (TIR) is a previously developed measure of glycemic control that expresses HbA1c stability over time within specific ranges. This measure may inform the current understanding of the association between glucose levels over time and ADRD incidence.<h4>Objective</h4>To examine the association between HbA1c TIR and incidence of ADRD in older veterans with 2024-01-01T00:00:00Z2024 Aug2026-06-01T22:17:55.939Z2025-02-19T04:39:00.468ZS-EPMC112973813909356310.1001/jamanetworkopen.2024.25354