{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(1)"],"submitter":["Garrido J"],"pubmed_abstract":["<h4>Background</h4>Tobacco use is one of the main risk factors for Lung Cancer (LC) development. However, about 10-20% of those diagnosed with the disease are never-smokers. For Non-Small Cell Lung Cancer (NSCLC) there are clear differences in both the clinical presentation and the tumor genomic profiles between smokers and never-smokers. For example, the Lung Adenocarcinoma (LUAD) histological subtype in never-smokers is predominately found in young women of European, North American, and Asian descent. While the clinical presentation and tumor genomic profiles of smokers have been widely examined, never-smokers are usually underrepresented, especially those of a Latin American (LA) background. In this work, we characterize, for the first time, the difference in the genomic profiles betwee"],"journal":["BMC cancer"],"pagination":["951"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11297669"],"repository":["biostudies-literature"],"pubmed_title":["Beyond tobacco: genomic disparities in lung cancer between smokers and never-smokers."],"pmcid":["PMC11297669"],"pubmed_authors":["Aren O","de Amorim MG","Aguila JF","Owen G","Freitas HC","Blanco A","Freire M","Armisen R","Perez P","Dias-Neto E","Ibanez C","Spencer ML","Bartelli TF","Bernal Y","Corvalan A","Lizana R","Olea MA","Fernandez C","Assar R","Ampuero D","Marcelain K","Chernilo S","Gonzalez E","Sepulveda-Hermosilla G","Rasse G","Garrido M","Sanchez C","Garrido J","Ramos L","Nunes DN","Rivas S","Caceres-Molina J","Orostica K","Dossetto GB"],"additional_accession":[]},"is_claimable":false,"name":"Beyond tobacco: genomic disparities in lung cancer between smokers and never-smokers.","description":"<h4>Background</h4>Tobacco use is one of the main risk factors for Lung Cancer (LC) development. However, about 10-20% of those diagnosed with the disease are never-smokers. For Non-Small Cell Lung Cancer (NSCLC) there are clear differences in both the clinical presentation and the tumor genomic profiles between smokers and never-smokers. For example, the Lung Adenocarcinoma (LUAD) histological subtype in never-smokers is predominately found in young women of European, North American, and Asian descent. While the clinical presentation and tumor genomic profiles of smokers have been widely examined, never-smokers are usually underrepresented, especially those of a Latin American (LA) background. In this work, we characterize, for the first time, the difference in the genomic profiles betwee","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-05-04T06:36:20.264Z","creation":"2026-04-22T03:09:45.16Z"},"accession":"S-EPMC11297669","cross_references":{"pubmed":["39097719"],"doi":["10.1186/s12885-024-12737-1"]}}