biostudies-literatureUnknown24(1)Garrido J<h4>Background</h4>Tobacco use is one of the main risk factors for Lung Cancer (LC) development. However, about 10-20% of those diagnosed with the disease are never-smokers. For Non-Small Cell Lung Cancer (NSCLC) there are clear differences in both the clinical presentation and the tumor genomic profiles between smokers and never-smokers. For example, the Lung Adenocarcinoma (LUAD) histological subtype in never-smokers is predominately found in young women of European, North American, and Asian descent. While the clinical presentation and tumor genomic profiles of smokers have been widely examined, never-smokers are usually underrepresented, especially those of a Latin American (LA) background. In this work, we characterize, for the first time, the difference in the genomic profiles betweeBMC cancer951https://www.ebi.ac.uk/biostudies/studies/S-EPMC11297669biostudies-literatureBeyond tobacco: genomic disparities in lung cancer between smokers and never-smokers.PMC11297669Aren Ode Amorim MGAguila JFOwen GFreitas HCBlanco AFreire MArmisen RPerez PDias-Neto EIbanez CSpencer MLBartelli TFBernal YCorvalan ALizana ROlea MAFernandez CAssar RAmpuero DMarcelain KChernilo SGonzalez ESepulveda-Hermosilla GRasse GGarrido MSanchez CGarrido JRamos LNunes DNRivas SCaceres-Molina JOrostica KDossetto GBfalseBeyond tobacco: genomic disparities in lung cancer between smokers and never-smokers.<h4>Background</h4>Tobacco use is one of the main risk factors for Lung Cancer (LC) development. However, about 10-20% of those diagnosed with the disease are never-smokers. For Non-Small Cell Lung Cancer (NSCLC) there are clear differences in both the clinical presentation and the tumor genomic profiles between smokers and never-smokers. For example, the Lung Adenocarcinoma (LUAD) histological subtype in never-smokers is predominately found in young women of European, North American, and Asian descent. While the clinical presentation and tumor genomic profiles of smokers have been widely examined, never-smokers are usually underrepresented, especially those of a Latin American (LA) background. In this work, we characterize, for the first time, the difference in the genomic profiles betwee2024-01-01T00:00:00Z2024 Aug2026-05-04T06:36:20.264Z2026-04-22T03:09:45.16ZS-EPMC112976693909771910.1186/s12885-024-12737-1