{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kirk JS"],"funding":["Roswell Park Alliance Foundation","Roswell Park Comprehensive Cancer Center","U.S. Department of Defense","NCI NIH HHS","National Institutes of Health","Prostate Cancer Foundation"],"pagination":["1203-1221.e7"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11297676"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["31(8)"],"pubmed_abstract":["Understanding prostate response to castration and androgen receptor signaling inhibitors (ARSI) is critical to improving long-term prostate cancer (PCa) patient survival. Here, we use a multi-omics approach on 229,794 single cells to create a mouse single-cell reference atlas for interpreting mouse prostate biology and castration response. Our reference atlas refines single-cell annotations and provides a chromatin context, which, when coupled with mouse lineage tracing, demonstrates that castration-resistant luminal cells are distinct from the pre-existent urethra-proximal stem/progenitor cells. Molecular pathway analysis and therapeutic studies further implicate AP1 (JUN/FOS), WNT/β-catenin, FOXQ1, NF-κB, and JAK/STAT pathways as major drivers of castration-resistant luminal populations "],"journal":["Cell stem cell"],"pubmed_title":["Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells."],"pmcid":["PMC11297676"],"funding_grant_id":["P30CA016056","R01CA240290","R01 CA240290","R21CA237939","R01 CA237027","R01 CA238005","R01CA237027","PC220137","R01CA238005","P30 CA016056","PC220273","U24 CA274159","R21 CA237939","R21CA218635","R21 CA218635"],"pubmed_authors":["Jamroze A","Tracz A","Singh PK","Wrana JL","Kirk JS","Huang J","Long M","Liu S","Liu T","Wang J","Kumar R","Yu H","Liu X","Tang DG","Cheng Q","Lovell J","Rosario S","Chatta G","Ji Y","Shen MM","Puzanov I"],"additional_accession":[]},"is_claimable":false,"name":"Integrated single-cell analysis defines the epigenetic basis of castration-resistant prostate luminal cells.","description":"Understanding prostate response to castration and androgen receptor signaling inhibitors (ARSI) is critical to improving long-term prostate cancer (PCa) patient survival. Here, we use a multi-omics approach on 229,794 single cells to create a mouse single-cell reference atlas for interpreting mouse prostate biology and castration response. Our reference atlas refines single-cell annotations and provides a chromatin context, which, when coupled with mouse lineage tracing, demonstrates that castration-resistant luminal cells are distinct from the pre-existent urethra-proximal stem/progenitor cells. Molecular pathway analysis and therapeutic studies further implicate AP1 (JUN/FOS), WNT/β-catenin, FOXQ1, NF-κB, and JAK/STAT pathways as major drivers of castration-resistant luminal populations ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-07-15T14:27:19.45Z","creation":"2025-08-18T09:54:23.584Z"},"accession":"S-EPMC11297676","cross_references":{"pubmed":["38878775"],"doi":["10.1016/j.stem.2024.05.008"]}}