{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Zhu C"],"pubmed_abstract":["<b>Background:</b> Glucagon-like peptide-1 (GLP-1) has crucial impact on glycemic control and weight loss physiologically. GLP-1 receptor agonists have been approved for treatment of diabetes and obesity. Emerging evidence suggests that GLP-1 receptor agonists exert anticancer effect in tumorigenesis and development. However, the role and mechanism of GLP-1 signaling-related genes in pan-cancer still need further study. <b>Methods:</b> We comprehensively investigated the aberrant expression and genetic alterations of GLP-1 signaling-related genes in 33 cancer types. Next, GLP-1 signaling score of each patient in The Cancer Genome Atlas were established by the single-sample gene set enrichment analysis. In addition, we explored the association of GLP-1 signaling score with prognostic signif"],"journal":["Frontiers in pharmacology"],"pagination":["1387243"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11298396"],"repository":["biostudies-literature"],"pubmed_title":["Comprehensively prognostic and immunological analyses of GLP-1 signaling-related genes in pan-cancer and validation in colorectal cancer."],"pmcid":["PMC11298396"],"pubmed_authors":["Fang Y","Lai Y","Zhu Y","Fu X","Lin X","Lai Q","Liu C","Liu S","Zhou X","Zhu C","Teng L"],"additional_accession":[]},"is_claimable":false,"name":"Comprehensively prognostic and immunological analyses of GLP-1 signaling-related genes in pan-cancer and validation in colorectal cancer.","description":"<b>Background:</b> Glucagon-like peptide-1 (GLP-1) has crucial impact on glycemic control and weight loss physiologically. GLP-1 receptor agonists have been approved for treatment of diabetes and obesity. Emerging evidence suggests that GLP-1 receptor agonists exert anticancer effect in tumorigenesis and development. However, the role and mechanism of GLP-1 signaling-related genes in pan-cancer still need further study. <b>Methods:</b> We comprehensively investigated the aberrant expression and genetic alterations of GLP-1 signaling-related genes in 33 cancer types. Next, GLP-1 signaling score of each patient in The Cancer Genome Atlas were established by the single-sample gene set enrichment analysis. In addition, we explored the association of GLP-1 signaling score with prognostic signif","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024","modification":"2026-06-01T13:20:38.681Z","creation":"2025-02-19T02:45:55.513Z"},"accession":"S-EPMC11298396","cross_references":{"pubmed":["39104385"],"doi":["10.3389/fphar.2024.1387243"]}}