biostudies-literatureUnknown14Shen J<h4>Introduction</h4>Desmoid tumor (DT) is a rare proliferative disease occurring in connective tissues, characterized by high infiltration and recurrence rates. While surgery remains the primary treatment, its recurrence risk is high, and some extra-abdominal desmoid tumors are inoperable due to their locations. Despite attempts with radiotherapy and systemic therapy, the efficacy remains limited.<h4>Methods</h4>We used low-power cumulative high-intensity focused ultrasound (HIFU) therapy as an initial treatment for desmoid tumor patients either ineligible or unwilling for surgery. Low-power cumulative HIFU employs slower heat accumulation and diffusion, minimizing damage to surrounding tissues while enhancing efficacy.<h4>Results</h4>Fifty-seven non-FAP desmoid tumor patients, previouslyFrontiers in oncology1388302https://www.ebi.ac.uk/biostudies/studies/S-EPMC11298426biostudies-literatureInitial treatment for surgery-naive desmoid tumors by high intensity focused ultrasound.PMC11298426Hu CShen JWu LHu XZhong XZhao JShen HXie SfalseInitial treatment for surgery-naive desmoid tumors by high intensity focused ultrasound.<h4>Introduction</h4>Desmoid tumor (DT) is a rare proliferative disease occurring in connective tissues, characterized by high infiltration and recurrence rates. While surgery remains the primary treatment, its recurrence risk is high, and some extra-abdominal desmoid tumors are inoperable due to their locations. Despite attempts with radiotherapy and systemic therapy, the efficacy remains limited.<h4>Methods</h4>We used low-power cumulative high-intensity focused ultrasound (HIFU) therapy as an initial treatment for desmoid tumor patients either ineligible or unwilling for surgery. Low-power cumulative HIFU employs slower heat accumulation and diffusion, minimizing damage to surrounding tissues while enhancing efficacy.<h4>Results</h4>Fifty-seven non-FAP desmoid tumor patients, previously2024-01-01T00:00:00Z20242025-06-01T00:59:24.258Z2025-06-01T00:59:24.258ZS-EPMC112984263910471810.3389/fonc.2024.1388302