biostudies-literatureUnknown15Wang Y<h4>Background</h4>The rising prevalence of herpes simplex type 2 (HSV-2) infection poses a growing global public health challenge. A comprehensive understanding of its epidemiology and burden disparities in China is crucial for informing targeted and effective intervention strategies in the future.<h4>Methods</h4>We followed Cochrane and PRISMA guidelines for a systematic review and included publications published in Chinese and English bibliographic systems until March 31^st, 2024. We synthesized HSV-2 seroprevalence data across different population types. We used random-effects models for meta-analyses and conducted meta-regression to assess the association between population characteristics and seroprevalence.<h4>Results</h4>Overall, 23,999 articles were identified, and 402 pFrontiers in immunology1369086https://www.ebi.ac.uk/biostudies/studies/S-EPMC11298463biostudies-literatureDisparities in burden of herpes simplex virus type 2 in China: systematic review, meta-analyses, and meta-regressions.PMC11298463Ai WHu SLi FJia YWang YTang WYan XFan CDai YXue HfalseDisparities in burden of herpes simplex virus type 2 in China: systematic review, meta-analyses, and meta-regressions.<h4>Background</h4>The rising prevalence of herpes simplex type 2 (HSV-2) infection poses a growing global public health challenge. A comprehensive understanding of its epidemiology and burden disparities in China is crucial for informing targeted and effective intervention strategies in the future.<h4>Methods</h4>We followed Cochrane and PRISMA guidelines for a systematic review and included publications published in Chinese and English bibliographic systems until March 31^st, 2024. We synthesized HSV-2 seroprevalence data across different population types. We used random-effects models for meta-analyses and conducted meta-regression to assess the association between population characteristics and seroprevalence.<h4>Results</h4>Overall, 23,999 articles were identified, and 402 p2024-01-01T00:00:00Z20242025-04-22T21:48:28.214Z2025-04-06T03:45:48.634ZS-EPMC112984633910454010.3389/fimmu.2024.1369086