{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["45(4)"],"submitter":["Fu Y"],"pubmed_abstract":["Tumor necrosis factor α (TNFα) exhibits diverse biological functions; however, its regulatory roles in myogenesis are not fully understood. In the present study, we explored the function of <i>TNFα</i> in myoblast proliferation, differentiation, migration, and myotube fusion in primary myoblasts and C2C12 cells. To this end, we constructed <i>TNFα</i> muscle-conditional knockout ( <i>TNFα</i>-CKO) mice and compared them with <i>flox</i> mice to assess the effects of <i>TNFα</i> knockout on skeletal muscles. Results indicated that <i>TNFα</i>-CKO mice displayed phenotypes such as accelerated muscle development, enhanced regenerative capacity, and improved exercise endurance compared to <i>flox</i> mice, with no significant differences observed in major visceral organs or skeletal structure."],"journal":["Zoological research"],"pagination":["951-960"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11298682"],"repository":["biostudies-literature"],"pubmed_title":["Tumor necrosis factor α deficiency promotes myogenesis and muscle regeneration."],"pmcid":["PMC11298682"],"pubmed_authors":["Shang P","Yan DW","Zhang H","Fu Y","Hao X","Zhang B","Nie JR"],"additional_accession":[]},"is_claimable":false,"name":"Tumor necrosis factor α deficiency promotes myogenesis and muscle regeneration.","description":"Tumor necrosis factor α (TNFα) exhibits diverse biological functions; however, its regulatory roles in myogenesis are not fully understood. In the present study, we explored the function of <i>TNFα</i> in myoblast proliferation, differentiation, migration, and myotube fusion in primary myoblasts and C2C12 cells. To this end, we constructed <i>TNFα</i> muscle-conditional knockout ( <i>TNFα</i>-CKO) mice and compared them with <i>flox</i> mice to assess the effects of <i>TNFα</i> knockout on skeletal muscles. Results indicated that <i>TNFα</i>-CKO mice displayed phenotypes such as accelerated muscle development, enhanced regenerative capacity, and improved exercise endurance compared to <i>flox</i> mice, with no significant differences observed in major visceral organs or skeletal structure.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2026-06-01T15:25:13.33Z","creation":"2025-02-19T04:40:27.522Z"},"accession":"S-EPMC11298682","cross_references":{"pubmed":["39021083"],"doi":["10.24272/j.issn.2095-8137.2024.039"]}}