biostudies-literatureBonelli JFundaci?n Cient?fica Asociaci?n Espa?ola Contra el C?ncerDepartament d&apos;Innovaci?, Universitats i Empresa, Generalitat de CatalunyaAgencia Estatal de Investigaci?nMinisterio de Ciencia e Innovaci?n38916-38930https://www.ebi.ac.uk/biostudies/studies/S-EPMC11299137biostudies-literatureUnknown16(30)Despite the potential of photodynamic therapy (PDT) in cancer treatment, the development of efficient and photostable photosensitizing molecules that operate at long wavelengths of light has become a major hurdle. Here, we report for the first time an Ir(III)-phthalocyanine conjugate (<b>Ir-ZnPc</b>) as a novel photosensitizer for high-efficiency synergistic PDT treatment that takes advantage of the long-wavelength excitation and near infrared (NIR) emission of the phthalocyanine scaffold and the known photostability and high phototoxicity of cyclometalated Ir(III) complexes. In order to increase water solubility and cell membrane permeability, the conjugate and parent zinc phthalocyanine (<b>ZnPc</b>) were encapsulated in amphoteric redox-responsive polyurethane-polyurea hybrid nanocapsulACS applied materials & interfacesA Nanoencapsulated Ir(III)-Phthalocyanine Conjugate as a Promising Photodynamic Therapy Anticancer Agent.PMC11299137PRDMU19003ORTE2017 DI 072RTI2018-096891-B-I00PID2020-117508RB-I00PID2021-122850NB-I00PID2020-117855RB-I00Lopez-Corrales MMarchan VFollana-Berna JOrtiz JAshoo PIzquierdo-Garcia ERocas JOrtega-Forte ESastre-Santos ABosch MRuiz JIsidro NAbad-Montero DVigueras GBonelli JHernandez AfalseA Nanoencapsulated Ir(III)-Phthalocyanine Conjugate as a Promising Photodynamic Therapy Anticancer Agent.Despite the potential of photodynamic therapy (PDT) in cancer treatment, the development of efficient and photostable photosensitizing molecules that operate at long wavelengths of light has become a major hurdle. Here, we report for the first time an Ir(III)-phthalocyanine conjugate (<b>Ir-ZnPc</b>) as a novel photosensitizer for high-efficiency synergistic PDT treatment that takes advantage of the long-wavelength excitation and near infrared (NIR) emission of the phthalocyanine scaffold and the known photostability and high phototoxicity of cyclometalated Ir(III) complexes. In order to increase water solubility and cell membrane permeability, the conjugate and parent zinc phthalocyanine (<b>ZnPc</b>) were encapsulated in amphoteric redox-responsive polyurethane-polyurea hybrid nanocapsul2024-01-01T00:00:00Z2024 Jul2025-04-05T15:03:13.79Z2025-02-19T04:40:29.468ZS-EPMC112991373904145310.1021/acsami.4c05181