{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["San Jacinto Garcia J"],"funding":["Knut och Alice Wallenbergs Stiftelse","HORIZON EUROPE European Innovation Council"],"pagination":["40056-40068"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11299145"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(30)"],"pubmed_abstract":["Open reduction internal fixation metal plates and screws remain the established standard-of-care for complex fracture fixation. They, however, have drawbacks such as limited customization, soft-tissue adhesions, and a lack of degradation. Bone cements and composites are being developed as alternative fixation techniques in order to overcome these issues. One such composite is a strong, stiff, and shapeable hydroxyapatite-containing material consisting of 1,3,5-triazine-2,4,6-trione (TATO) monomers, which cures through high energy visible light-induced thiol-ene coupling (TEC) chemistry. Previous human cadaver and in vivo studies have shown that patches of this composite provide sufficient fixation for healing bone fractures; however, the composite lacks degradability. To promote degradatio"],"journal":["ACS applied materials & interfaces"],"pubmed_title":["Enhanced Degradability of Thiol-Ene Composites through the Inclusion of Isosorbide-Based Polycarbonates."],"pmcid":["PMC11299145"],"funding_grant_id":["952150","101064084","2017.0300"],"pubmed_authors":["Hutchinson DJ","Malkoch M","San Jacinto Garcia J","Sanz Del Olmo N"],"additional_accession":[]},"is_claimable":false,"name":"Enhanced Degradability of Thiol-Ene Composites through the Inclusion of Isosorbide-Based Polycarbonates.","description":"Open reduction internal fixation metal plates and screws remain the established standard-of-care for complex fracture fixation. They, however, have drawbacks such as limited customization, soft-tissue adhesions, and a lack of degradation. Bone cements and composites are being developed as alternative fixation techniques in order to overcome these issues. One such composite is a strong, stiff, and shapeable hydroxyapatite-containing material consisting of 1,3,5-triazine-2,4,6-trione (TATO) monomers, which cures through high energy visible light-induced thiol-ene coupling (TEC) chemistry. Previous human cadaver and in vivo studies have shown that patches of this composite provide sufficient fixation for healing bone fractures; however, the composite lacks degradability. To promote degradatio","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-04-05T15:02:42.438Z","creation":"2025-02-19T04:40:55.986Z"},"accession":"S-EPMC11299145","cross_references":{"pubmed":["39031473"],"doi":["10.1021/acsami.4c09626"]}}