biostudies-literatureSan Jacinto Garcia JKnut och Alice Wallenbergs StiftelseHORIZON EUROPE European Innovation Council40056-40068https://www.ebi.ac.uk/biostudies/studies/S-EPMC11299145biostudies-literatureUnknown16(30)Open reduction internal fixation metal plates and screws remain the established standard-of-care for complex fracture fixation. They, however, have drawbacks such as limited customization, soft-tissue adhesions, and a lack of degradation. Bone cements and composites are being developed as alternative fixation techniques in order to overcome these issues. One such composite is a strong, stiff, and shapeable hydroxyapatite-containing material consisting of 1,3,5-triazine-2,4,6-trione (TATO) monomers, which cures through high energy visible light-induced thiol-ene coupling (TEC) chemistry. Previous human cadaver and in vivo studies have shown that patches of this composite provide sufficient fixation for healing bone fractures; however, the composite lacks degradability. To promote degradatioACS applied materials & interfacesEnhanced Degradability of Thiol-Ene Composites through the Inclusion of Isosorbide-Based Polycarbonates.PMC112991459521501010640842017.0300Hutchinson DJMalkoch MSan Jacinto Garcia JSanz Del Olmo NfalseEnhanced Degradability of Thiol-Ene Composites through the Inclusion of Isosorbide-Based Polycarbonates.Open reduction internal fixation metal plates and screws remain the established standard-of-care for complex fracture fixation. They, however, have drawbacks such as limited customization, soft-tissue adhesions, and a lack of degradation. Bone cements and composites are being developed as alternative fixation techniques in order to overcome these issues. One such composite is a strong, stiff, and shapeable hydroxyapatite-containing material consisting of 1,3,5-triazine-2,4,6-trione (TATO) monomers, which cures through high energy visible light-induced thiol-ene coupling (TEC) chemistry. Previous human cadaver and in vivo studies have shown that patches of this composite provide sufficient fixation for healing bone fractures; however, the composite lacks degradability. To promote degradatio2024-01-01T00:00:00Z2024 Jul2025-04-05T15:02:42.438Z2025-02-19T04:40:55.986ZS-EPMC112991453903147310.1021/acsami.4c09626