{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gu Y"],"funding":["National Natural Science Foundation of China"],"pagination":["2378210"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11299449"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["46(2)"],"pubmed_abstract":["<b>Objectives:</b> To explore the therapeutic effects of M2 macrophages in diabetic nephropathy (DN) and their mechanism.<b>Methods:</b> We infused M2 macrophages stimulated with IL-4 into 10-week-old db/db mice once a week for 4 weeks through the tail vein as M2 group. Then we investigated the role of M2 macrophages in alleviating the infammation of DN and explored the mechanism.<b>Results:</b> M2 macrophages hindered the progression of DN, reduced the levels of IL-1β (DN group was 34%, M2 group was 13%, <i>p</i> < 0.01) and MCP-1 (DN group was 49%, M2 group was 16%, <i>p</i> < 0.01) in the glomeruli. It was also proven that M2 macrophages alleviate mesangial cell injury caused by a high glucose environment. M2 macrophage tracking showed that the infused M2 macrophages migrated to the kid"],"journal":["Renal failure"],"pubmed_title":["M2 macrophage infusion ameliorates diabetic glomerulopathy <i>via</i> the JAK2/STAT3 pathway in db/db mice."],"pmcid":["PMC11299449"],"funding_grant_id":["81870578"],"pubmed_authors":["Yin Y","Liu J","Gu Y","Yu S","Lyu Z","Mu Y","Gu W","Zhang H","Yuan M","Guo Q","Zhang Q","Cheng Y","Li B","Xue J"],"additional_accession":[]},"is_claimable":false,"name":"M2 macrophage infusion ameliorates diabetic glomerulopathy <i>via</i> the JAK2/STAT3 pathway in db/db mice.","description":"<b>Objectives:</b> To explore the therapeutic effects of M2 macrophages in diabetic nephropathy (DN) and their mechanism.<b>Methods:</b> We infused M2 macrophages stimulated with IL-4 into 10-week-old db/db mice once a week for 4 weeks through the tail vein as M2 group. Then we investigated the role of M2 macrophages in alleviating the infammation of DN and explored the mechanism.<b>Results:</b> M2 macrophages hindered the progression of DN, reduced the levels of IL-1β (DN group was 34%, M2 group was 13%, <i>p</i> < 0.01) and MCP-1 (DN group was 49%, M2 group was 16%, <i>p</i> < 0.01) in the glomeruli. It was also proven that M2 macrophages alleviate mesangial cell injury caused by a high glucose environment. M2 macrophage tracking showed that the infused M2 macrophages migrated to the kid","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Dec","modification":"2025-04-05T15:02:52.712Z","creation":"2025-02-19T04:41:01.013Z"},"accession":"S-EPMC11299449","cross_references":{"pubmed":["39090966"],"doi":["10.1080/0886022X.2024.2378210"]}}