{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(14)"],"submitter":["Wei X"],"pubmed_abstract":["Leukemia is a malignant tumor of the hematologic system. Studies have shown that cernuumolide J (TMJ-105), an extract of <i>Carpesium cernuum</i>, has anti-cancer effects, but the underlying mechanism is unclear. In this study, we investigated the effect of TMJ-105 on the proliferation of human leukemia HEL cells and its molecular mechanism. MTT analysis showed TMJ-105 had revealed that it shows significant IC<sub>50</sub> in HEL cells at lower doses (1.79 ± 0.29 μmol/L) than in K562 cells (3.89 ± 0.80 μmol/L), and the suppression of HEL cell proliferation was time- and concentration-dependent. Meanwhile, TMJ-105 induced G2/M phase blockage, leading to DNA damage in HEL cells. TMJ-105 promoted HEL cells to release of reactive oxygen species (ROS) and changed mitochondrial membrane potentia"],"journal":["Heliyon"],"pagination":["e34115"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11301199"],"repository":["biostudies-literature"],"pubmed_title":["TMJ-105, an extract of <i>Carpesium cernuum</i>, induced G2/M phase arrest and apoptosis via the JAK2/STAT3 axis and MAPKs signaling pathway in leukemia HEL cells."],"pmcid":["PMC11301199"],"pubmed_authors":["Rao Q","Li Y","Huang Y","Liang W","Liu Q","Wei X","Yan C","Feng S","Song J"],"additional_accession":[]},"is_claimable":false,"name":"TMJ-105, an extract of <i>Carpesium cernuum</i>, induced G2/M phase arrest and apoptosis via the JAK2/STAT3 axis and MAPKs signaling pathway in leukemia HEL cells.","description":"Leukemia is a malignant tumor of the hematologic system. Studies have shown that cernuumolide J (TMJ-105), an extract of <i>Carpesium cernuum</i>, has anti-cancer effects, but the underlying mechanism is unclear. In this study, we investigated the effect of TMJ-105 on the proliferation of human leukemia HEL cells and its molecular mechanism. MTT analysis showed TMJ-105 had revealed that it shows significant IC<sub>50</sub> in HEL cells at lower doses (1.79 ± 0.29 μmol/L) than in K562 cells (3.89 ± 0.80 μmol/L), and the suppression of HEL cell proliferation was time- and concentration-dependent. Meanwhile, TMJ-105 induced G2/M phase blockage, leading to DNA damage in HEL cells. TMJ-105 promoted HEL cells to release of reactive oxygen species (ROS) and changed mitochondrial membrane potentia","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Jul","modification":"2025-06-01T00:58:59.203Z","creation":"2025-06-01T00:58:59.203Z"},"accession":"S-EPMC11301199","cross_references":{"pubmed":["39108922"],"doi":["10.1016/j.heliyon.2024.e34115"]}}