{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(1)"],"submitter":["Chow JY"],"funding":["Lee Kong Chian School of Medicine—Ministry of Education Start-Up Grant"],"pubmed_abstract":["<h4>Background</h4>Wolbachia symbiosis in Aedes aegypti is an emerging biocontrol measure against dengue. However, assessing its real-world efficacy is challenging due to the non-randomised, field-based nature of most intervention studies. This research re-evaluates the spatial-temporal impact of Wolbachia interventions on dengue incidence using a large battery of quasi-experimental methods and assesses each method's validity.<h4>Methods</h4>A systematic search for Wolbachia intervention data was conducted via PUBMED. Efficacy was reassessed using commonly-used quasi-experimental approaches with extensive robustness checks, including geospatial placebo tests and a simulation study. Intervention efficacies across multiple study sites were computed using high-resolution aggregations to exami"],"journal":["BMC medical research methodology"],"pagination":["170"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11302844"],"repository":["biostudies-literature"],"pubmed_title":["Evaluating quasi-experimental approaches for estimating epidemiological efficacy of non-randomised field trials: applications in Wolbachia interventions for dengue."],"pmcid":["PMC11302844"],"pubmed_authors":["Lim JT","Hoffmann AA","Bansal S","Ng LC","Geng L","Dickens BSL","Chow JY"],"additional_accession":[]},"is_claimable":false,"name":"Evaluating quasi-experimental approaches for estimating epidemiological efficacy of non-randomised field trials: applications in Wolbachia interventions for dengue.","description":"<h4>Background</h4>Wolbachia symbiosis in Aedes aegypti is an emerging biocontrol measure against dengue. However, assessing its real-world efficacy is challenging due to the non-randomised, field-based nature of most intervention studies. This research re-evaluates the spatial-temporal impact of Wolbachia interventions on dengue incidence using a large battery of quasi-experimental methods and assesses each method's validity.<h4>Methods</h4>A systematic search for Wolbachia intervention data was conducted via PUBMED. Efficacy was reassessed using commonly-used quasi-experimental approaches with extensive robustness checks, including geospatial placebo tests and a simulation study. Intervention efficacies across multiple study sites were computed using high-resolution aggregations to exami","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-04T02:57:31.696Z","creation":"2025-02-19T04:40:01.802Z"},"accession":"S-EPMC11302844","cross_references":{"pubmed":["39107710"],"doi":["10.1186/s12874-024-02291-6"]}}