{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["31(8)"],"submitter":["Deng N"],"pubmed_abstract":["Uterine luminal epithelia (LE), the first layer contacting with the blastocyst, acquire receptivity for normal embryo implantation. Besides the well-accepted transcriptional regulation dominated by ovarian estrogen and progesterone for receptivity establishment, the involvement of epigenetic mechanisms remains elusive. This study systematically profiles the transcriptome and genome-wide H3K27me3 distribution in the LE throughout the preimplantation. Combining genetic and pharmacological approaches targeting the PRC2 core enzyme Ezh1/2, we demonstrate that the defective remodeling of H3K27me3 in the preimplantation stage disrupts the differentiation of LE, and derails uterine receptivity, resulting in implantation failure. Specifically, crucial epithelial genes, Pgr, Gata2, and Sgk1, are tr"],"journal":["Cell death and differentiation"],"pagination":["1013-1028"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11303564"],"repository":["biostudies-literature"],"pubmed_title":["H3K27me3 timely dictates uterine epithelial transcriptome remodeling and thus transformation essential for normal embryo implantation."],"pmcid":["PMC11303564"],"pubmed_authors":["Li G","Deng N","Liu M","Zhang L","Wang H","Cai H","Wang P","Lu J","Bao H","Kong S","He B","Deng W","Tang Y"],"additional_accession":[]},"is_claimable":false,"name":"H3K27me3 timely dictates uterine epithelial transcriptome remodeling and thus transformation essential for normal embryo implantation.","description":"Uterine luminal epithelia (LE), the first layer contacting with the blastocyst, acquire receptivity for normal embryo implantation. Besides the well-accepted transcriptional regulation dominated by ovarian estrogen and progesterone for receptivity establishment, the involvement of epigenetic mechanisms remains elusive. This study systematically profiles the transcriptome and genome-wide H3K27me3 distribution in the LE throughout the preimplantation. Combining genetic and pharmacological approaches targeting the PRC2 core enzyme Ezh1/2, we demonstrate that the defective remodeling of H3K27me3 in the preimplantation stage disrupts the differentiation of LE, and derails uterine receptivity, resulting in implantation failure. Specifically, crucial epithelial genes, Pgr, Gata2, and Sgk1, are tr","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-03-18T13:22:25.48Z","creation":"2025-08-18T09:53:58.533Z"},"accession":"S-EPMC11303564","cross_references":{"pubmed":["38698061"],"doi":["10.1038/s41418-024-01302-9"]}}