{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(31)"],"submitter":["Selinger AJ"],"pubmed_abstract":["Here we report a systems chemistry oriented approach for developing information-rich mixed host chemosensors. We show that co-assembling macrocyclic hosts from different classes, DimerDye sulfonatocalix[4]arenes and cucurbit[<i>n</i>]urils, effectively increases the scope of analyte binding interactions and therefore, sensory outputs. This simple dynamic strategy exploits cross-reactive noncovalent host-host complexation interactions while integrating a reporter dye, thereby producing emergent photophysical responses when an analyte interacts with either host. We first demonstrate the advantages of mixed host co-assembled chemosensors through an increased detection range of hydrophobic, cationic, neutral, and anionic drugs. We then implement mixed host sensors in an array-based platform for the differentiation of illicit drugs, including cannabinoids, benzodiazepine analogs, opiates, anesthetics, amphetamine, and common adulterating substances. Finally, the potential of this approach is applied to profiling real-world multi-component illicit street drug samples, proving to be more effective than classical sensor arrays."],"journal":["Chemical science"],"pagination":["12388-12397"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11304549"],"repository":["biostudies-literature"],"pubmed_title":["Mixed host co-assembled systems for broad-scope analyte sensing."],"pmcid":["PMC11304549"],"pubmed_authors":["Hore D","Poarch E","Selinger AJ","Biedermann F","Kramer J","Hof F"],"additional_accession":[]},"is_claimable":false,"name":"Mixed host co-assembled systems for broad-scope analyte sensing.","description":"Here we report a systems chemistry oriented approach for developing information-rich mixed host chemosensors. We show that co-assembling macrocyclic hosts from different classes, DimerDye sulfonatocalix[4]arenes and cucurbit[<i>n</i>]urils, effectively increases the scope of analyte binding interactions and therefore, sensory outputs. This simple dynamic strategy exploits cross-reactive noncovalent host-host complexation interactions while integrating a reporter dye, thereby producing emergent photophysical responses when an analyte interacts with either host. We first demonstrate the advantages of mixed host co-assembled chemosensors through an increased detection range of hydrophobic, cationic, neutral, and anionic drugs. We then implement mixed host sensors in an array-based platform for the differentiation of illicit drugs, including cannabinoids, benzodiazepine analogs, opiates, anesthetics, amphetamine, and common adulterating substances. Finally, the potential of this approach is applied to profiling real-world multi-component illicit street drug samples, proving to be more effective than classical sensor arrays.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-05T11:09:44.353Z","creation":"2025-04-05T11:09:44.353Z"},"accession":"S-EPMC11304549","cross_references":{"pubmed":["39118638"],"doi":["10.1039/d4sc02788d"]}}