{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Troeman DPR"],"funding":["Innovative Medicines Initiative","European Federation of Pharmaceutical Industries and Associations","European Union Seventh Framework Programme"],"pagination":["ofae414"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11304588"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(8)"],"pubmed_abstract":["<h4>Background</h4>The independent effects of extranasal-only carriage, carriage at multiple bodily sites, or the bacterial load of colonizing <i>Staphylococcus aureus</i> (SA) on the risk of developing SA surgical site infections and postoperative bloodstream infections (SA SSI/BSIs) are unclear. We aimed to quantify these effects in this large prospective cohort study.<h4>Methods</h4>Surgical patients aged 18 years or older were screened for SA carriage in the nose, throat, or perineum within 30 days before surgery. SA carriers and noncarriers were enrolled in a prospective cohort study in a 2:1 ratio. Weighted multivariable Cox proportional hazard models were used to assess the independent associations between different measures of SA carriage and occurrence of SA SSI/BSI within 90 days"],"journal":["Open forum infectious diseases"],"pubmed_title":["Association of <i>Staphylococcus aureus</i> Bacterial Load and Colonization Sites With the Risk of Postoperative <i>S. aureus</i> Infection."],"pmcid":["PMC11304588"],"funding_grant_id":["FP7/2007-2013","115523"],"pubmed_authors":["Brat R","Van Rooij S","Couperus J","Barbadoro P","van der Laan L","Neumann J","Chapelle S","Kluytmans JAJW","Malhotra-Kumar S","Chadwick D","Paling F","de la Torre Cisneros J","Mitt P","Rojo MP","Djordjevic Z","Recanatini C","van Werkhoven CHW","Hazard D","Harbarth S","Bonten M","Wolkewitz M","Del Toro Lopez MD","Escudero D","Bryssinck L","Corneci D","Horcajada JP","Vierhout B","Turconi SIB","van Esschoten M","Bateman T","Vlaeminck J","Schasfoort E","Brugman C","Solomon S","Ruzin A","Castelli F","Altmets M","Tomas T","Corthals S","Ustianowski A","Todor A","Sifakis F","Nardi G","Vanderstraeten A","Selman B","Laffut W","Lammens C","Couve-Deacon E","Mawer D","Timbermont L","David M","Van den Abeele A","Vilken T","Troeman DPR","Coenjaerts F","Carevic B","ASPIRE-SSI Study Group","Sandesc D","Xavier BB","Van Beek K","Goossens H","Gheorghita V","Cuperus N","Llewelyn M","Konstantinovic S","Tkaczyk C","Weber S","Hanke I","Ekkelenkamp M"],"additional_accession":[]},"is_claimable":false,"name":"Association of <i>Staphylococcus aureus</i> Bacterial Load and Colonization Sites With the Risk of Postoperative <i>S. aureus</i> Infection.","description":"<h4>Background</h4>The independent effects of extranasal-only carriage, carriage at multiple bodily sites, or the bacterial load of colonizing <i>Staphylococcus aureus</i> (SA) on the risk of developing SA surgical site infections and postoperative bloodstream infections (SA SSI/BSIs) are unclear. We aimed to quantify these effects in this large prospective cohort study.<h4>Methods</h4>Surgical patients aged 18 years or older were screened for SA carriage in the nose, throat, or perineum within 30 days before surgery. SA carriers and noncarriers were enrolled in a prospective cohort study in a 2:1 ratio. Weighted multivariable Cox proportional hazard models were used to assess the independent associations between different measures of SA carriage and occurrence of SA SSI/BSI within 90 days","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-06-01T09:57:36.17Z","creation":"2024-11-09T17:31:42.673Z"},"accession":"S-EPMC11304588","cross_references":{"pubmed":["39113829"],"doi":["10.1093/ofid/ofae414"]}}