biostudies-literatureTroeman DPRInnovative Medicines InitiativeEuropean Federation of Pharmaceutical Industries and AssociationsEuropean Union Seventh Framework Programmeofae414https://www.ebi.ac.uk/biostudies/studies/S-EPMC11304588biostudies-literatureUnknown11(8)<h4>Background</h4>The independent effects of extranasal-only carriage, carriage at multiple bodily sites, or the bacterial load of colonizing <i>Staphylococcus aureus</i> (SA) on the risk of developing SA surgical site infections and postoperative bloodstream infections (SA SSI/BSIs) are unclear. We aimed to quantify these effects in this large prospective cohort study.<h4>Methods</h4>Surgical patients aged 18 years or older were screened for SA carriage in the nose, throat, or perineum within 30 days before surgery. SA carriers and noncarriers were enrolled in a prospective cohort study in a 2:1 ratio. Weighted multivariable Cox proportional hazard models were used to assess the independent associations between different measures of SA carriage and occurrence of SA SSI/BSI within 90 daysOpen forum infectious diseasesAssociation of <i>Staphylococcus aureus</i> Bacterial Load and Colonization Sites With the Risk of Postoperative <i>S. aureus</i> Infection.PMC11304588FP7/2007-2013115523Brat RVan Rooij SCouperus JBarbadoro Pvan der Laan LNeumann JChapelle SKluytmans JAJWMalhotra-Kumar SChadwick DPaling Fde la Torre Cisneros JMitt PRojo MPDjordjevic ZRecanatini Cvan Werkhoven CHWHazard DHarbarth SBonten MWolkewitz MDel Toro Lopez MDEscudero DBryssinck LCorneci DHorcajada JPVierhout BTurconi SIBvan Esschoten MBateman TVlaeminck JSchasfoort EBrugman CSolomon SRuzin ACastelli FAltmets MTomas TCorthals SUstianowski ATodor ASifakis FNardi GVanderstraeten ASelman BLaffut WLammens CCouve-Deacon EMawer DTimbermont LDavid MVan den Abeele AVilken TTroeman DPRCoenjaerts FCarevic BASPIRE-SSI Study GroupSandesc DXavier BBVan Beek KGoossens HGheorghita VCuperus NLlewelyn MKonstantinovic STkaczyk CWeber SHanke IEkkelenkamp MfalseAssociation of <i>Staphylococcus aureus</i> Bacterial Load and Colonization Sites With the Risk of Postoperative <i>S. aureus</i> Infection.<h4>Background</h4>The independent effects of extranasal-only carriage, carriage at multiple bodily sites, or the bacterial load of colonizing <i>Staphylococcus aureus</i> (SA) on the risk of developing SA surgical site infections and postoperative bloodstream infections (SA SSI/BSIs) are unclear. We aimed to quantify these effects in this large prospective cohort study.<h4>Methods</h4>Surgical patients aged 18 years or older were screened for SA carriage in the nose, throat, or perineum within 30 days before surgery. SA carriers and noncarriers were enrolled in a prospective cohort study in a 2:1 ratio. Weighted multivariable Cox proportional hazard models were used to assess the independent associations between different measures of SA carriage and occurrence of SA SSI/BSI within 90 days2024-01-01T00:00:00Z2024 Aug2026-06-01T09:57:36.17Z2024-11-09T17:31:42.673ZS-EPMC113045883911382910.1093/ofid/ofae414