biostudies-literatureUnknown6(1)Griessmair M<h4>Background</h4>Molecular glioblastoma (molGB) does not exhibit the histologic hallmarks of a grade 4 glioma but is nevertheless diagnosed as glioblastoma when harboring specific molecular markers. MolGB can easily be mistaken for similar-appearing lower-grade astrocytomas. Here, we investigated how advanced imaging could reflect the underlying tumor biology.<h4>Methods</h4>Clinical and imaging data were collected for 7 molGB grade 4, 9 astrocytomas grade 2, and 12 astrocytomas grade 3. Four neuroradiologists performed VASARI-scoring of conventional imaging, and their inter-reader agreement was assessed using Fleiss κ coefficient. To evaluate the potential of advanced imaging, 2-sample <i>t</i> test, 1-way ANOVA, Mann-Whitney U, and Kruskal-Wallis test were performed to test for signifiNeuro-oncology advancesvdae106https://www.ebi.ac.uk/biostudies/studies/S-EPMC11304596biostudies-literatureExploring molecular glioblastoma: Insights from advanced imaging for a nuanced understanding of the molecularly defined malignant biology.PMC11304596Bernhardt DMeyer BKertels OSchramm SJung KGriessmair MSchmidt-Graf FMetz MCYakushev IThomas MZiegenfeuter JDelbridge CZimmer CWiestler BCombs SEMueller TfalseExploring molecular glioblastoma: Insights from advanced imaging for a nuanced understanding of the molecularly defined malignant biology.<h4>Background</h4>Molecular glioblastoma (molGB) does not exhibit the histologic hallmarks of a grade 4 glioma but is nevertheless diagnosed as glioblastoma when harboring specific molecular markers. MolGB can easily be mistaken for similar-appearing lower-grade astrocytomas. Here, we investigated how advanced imaging could reflect the underlying tumor biology.<h4>Methods</h4>Clinical and imaging data were collected for 7 molGB grade 4, 9 astrocytomas grade 2, and 12 astrocytomas grade 3. Four neuroradiologists performed VASARI-scoring of conventional imaging, and their inter-reader agreement was assessed using Fleiss κ coefficient. To evaluate the potential of advanced imaging, 2-sample <i>t</i> test, 1-way ANOVA, Mann-Whitney U, and Kruskal-Wallis test were performed to test for signifi2024-01-01T00:00:00Z2024 Jan-Dec2025-04-26T05:32:18.372Z2025-04-06T11:29:14.69ZS-EPMC113045963911418210.1093/noajnl/vdae106