{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Denny BT"],"funding":["NIMH NIH HHS","National Institute of Mental Health","Department of Veterans Affairs","CSRD VA"],"pagination":["819-826"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11305902"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9(8)"],"pubmed_abstract":["<h4>Background</h4>Borderline personality disorder (BPD) is the prototypical disorder of emotion dysregulation. We have previously shown that patients with BPD are impaired in their capacity to engage cognitive reappraisal, a frequently employed adaptive emotion regulation strategy.<h4>Methods</h4>Here, we report on the efficacy of longitudinal training in cognitive reappraisal to enhance emotion regulation in patients with BPD. Specifically, the training targeted psychological distancing, a reappraisal tactic whereby negative stimuli are viewed dispassionately as though experienced by an objective, impartial observer. At each of 5 sessions over 2 weeks, 22 participants with BPD (14 female) and 22 healthy control participants (13 female) received training in psychological distancing and th"],"journal":["Biological psychiatry. Cognitive neuroscience and neuroimaging"],"pubmed_title":["Training in Cognitive Reappraisal Normalizes Whole-Brain Indices of Emotion Regulation in Borderline Personality Disorder."],"pmcid":["PMC11305902"],"funding_grant_id":["IK6 CX001738","R01 MH077813","IK6 CX002700"],"pubmed_authors":["Galitzer H","Wu-Chung EL","Goodson PN","Denny BT","Schulz KP","Ochsner KN","Rosell DR","Goodman M","Koenigsberg HW","Martin Lopez M","Fels S","Dicker EE","New AS","McClure MM","Trumbull J","Fan J","Hazlett EA","Perez-Rodriguez MM","Lopez RB"],"additional_accession":[]},"is_claimable":false,"name":"Training in Cognitive Reappraisal Normalizes Whole-Brain Indices of Emotion Regulation in Borderline Personality Disorder.","description":"<h4>Background</h4>Borderline personality disorder (BPD) is the prototypical disorder of emotion dysregulation. We have previously shown that patients with BPD are impaired in their capacity to engage cognitive reappraisal, a frequently employed adaptive emotion regulation strategy.<h4>Methods</h4>Here, we report on the efficacy of longitudinal training in cognitive reappraisal to enhance emotion regulation in patients with BPD. Specifically, the training targeted psychological distancing, a reappraisal tactic whereby negative stimuli are viewed dispassionately as though experienced by an objective, impartial observer. At each of 5 sessions over 2 weeks, 22 participants with BPD (14 female) and 22 healthy control participants (13 female) received training in psychological distancing and th","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-03-18T13:37:57.018Z","creation":"2025-08-18T09:54:25.046Z"},"accession":"S-EPMC11305902","cross_references":{"pubmed":["38641208"],"doi":["10.1016/j.bpsc.2024.03.007"]}}