biostudies-literatureDenny BTNIMH NIH HHSNational Institute of Mental HealthDepartment of Veterans AffairsCSRD VA819-826https://www.ebi.ac.uk/biostudies/studies/S-EPMC11305902biostudies-literatureUnknown9(8)<h4>Background</h4>Borderline personality disorder (BPD) is the prototypical disorder of emotion dysregulation. We have previously shown that patients with BPD are impaired in their capacity to engage cognitive reappraisal, a frequently employed adaptive emotion regulation strategy.<h4>Methods</h4>Here, we report on the efficacy of longitudinal training in cognitive reappraisal to enhance emotion regulation in patients with BPD. Specifically, the training targeted psychological distancing, a reappraisal tactic whereby negative stimuli are viewed dispassionately as though experienced by an objective, impartial observer. At each of 5 sessions over 2 weeks, 22 participants with BPD (14 female) and 22 healthy control participants (13 female) received training in psychological distancing and thBiological psychiatry. Cognitive neuroscience and neuroimagingTraining in Cognitive Reappraisal Normalizes Whole-Brain Indices of Emotion Regulation in Borderline Personality Disorder.PMC11305902IK6 CX001738R01 MH077813IK6 CX002700Galitzer HWu-Chung ELGoodson PNDenny BTSchulz KPOchsner KNRosell DRGoodman MKoenigsberg HWMartin Lopez MFels SDicker EENew ASMcClure MMTrumbull JFan JHazlett EAPerez-Rodriguez MMLopez RBfalseTraining in Cognitive Reappraisal Normalizes Whole-Brain Indices of Emotion Regulation in Borderline Personality Disorder.<h4>Background</h4>Borderline personality disorder (BPD) is the prototypical disorder of emotion dysregulation. We have previously shown that patients with BPD are impaired in their capacity to engage cognitive reappraisal, a frequently employed adaptive emotion regulation strategy.<h4>Methods</h4>Here, we report on the efficacy of longitudinal training in cognitive reappraisal to enhance emotion regulation in patients with BPD. Specifically, the training targeted psychological distancing, a reappraisal tactic whereby negative stimuli are viewed dispassionately as though experienced by an objective, impartial observer. At each of 5 sessions over 2 weeks, 22 participants with BPD (14 female) and 22 healthy control participants (13 female) received training in psychological distancing and th2024-01-01T00:00:00Z2024 Aug2026-03-18T13:37:57.018Z2025-08-18T09:54:25.046ZS-EPMC113059023864120810.1016/j.bpsc.2024.03.007