{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Han L"],"funding":["National Natural Science Foundation of China"],"pagination":["746"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11308528"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["Acute graft-versus-host disease (aGVHD) is primarily driven by allogeneic donor T cells associated with an altered composition of the host gut microbiome and its metabolites. The severity of aGVHD after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is not solely determined by the host and donor characteristics; however, the underlying mechanisms remain unclear. Using single-cell RNA sequencing, we decoded the immune cell atlas of 12 patients who underwent allo-HSCT: six with aGVHD and six with non-aGVHD. We performed a fecal microbiota (16SrRNA sequencing) analysis to investigate the fecal bacterial composition of 82 patients: 30 with aGVHD and 52 with non-aGVHD. Fecal samples from these patients were analyzed for bile acid metabolism. Through multi-omic analysis, we ident"],"journal":["Journal of translational medicine"],"pubmed_title":["Multi-omics analysis reveals a feedback loop amplifying immune responses in acute graft-versus-host disease due to imbalanced gut microbiota and bile acid metabolism."],"pmcid":["PMC11308528"],"funding_grant_id":["82100240"],"pubmed_authors":["Chen Q","Li J","Zhang D","Zhu Z","Han L","Xin Q","Zhang M","Sun X","Kong J","Bai Y","Zhou Y","Guo R","Yang F","Jiang Y","Sun N","Feng K","Wang S","Yue B","Gao Y","Fu L","Chen Y","Wang X","Yang Q","Zhao J"],"additional_accession":[]},"is_claimable":false,"name":"Multi-omics analysis reveals a feedback loop amplifying immune responses in acute graft-versus-host disease due to imbalanced gut microbiota and bile acid metabolism.","description":"Acute graft-versus-host disease (aGVHD) is primarily driven by allogeneic donor T cells associated with an altered composition of the host gut microbiome and its metabolites. The severity of aGVHD after allogeneic hematopoietic stem cell transplantation (allo-HSCT) is not solely determined by the host and donor characteristics; however, the underlying mechanisms remain unclear. Using single-cell RNA sequencing, we decoded the immune cell atlas of 12 patients who underwent allo-HSCT: six with aGVHD and six with non-aGVHD. We performed a fecal microbiota (16SrRNA sequencing) analysis to investigate the fecal bacterial composition of 82 patients: 30 with aGVHD and 52 with non-aGVHD. Fecal samples from these patients were analyzed for bile acid metabolism. Through multi-omic analysis, we ident","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-04-30T00:01:11.26Z","creation":"2024-11-20T12:34:30.054Z"},"accession":"S-EPMC11308528","cross_references":{"pubmed":["39113144"],"doi":["10.1186/s12967-024-05577-x"]}}