{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Yoo D"],"funding":["NIA NIH HHS","NIAID NIH HHS","NIMH NIH HHS","NHGRI NIH HHS","NLM NIH HHS","NIGMS NIH HHS","NIH HHS"],"pubmed_abstract":["We present haplotype-resolved reference genomes and comparative analyses of six ape species, namely: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan, and siamang. We achieve chromosome-level contiguity with unparalleled sequence accuracy (<1 error in 500,000 base pairs), completely sequencing 215 gapless chromosomes telomere-to-telomere. We resolve challenging regions, such as the major histocompatibility complex and immunoglobulin loci, providing more in-depth evolutionary insights. Comparative analyses, including human, allow us to investigate the evolution and diversity of regions previously uncharacterized or incompletely studied without bias from mapping to the human reference. This includes newly minted gene families within lineage-specific segmental duplications, "],"journal":["bioRxiv : the preprint server for biology"],"pagination":["2024.07.31.605654"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11312596"],"repository":["biostudies-literature"],"pubmed_title":["Complete sequencing of ape genomes."],"pmcid":["PMC11312596"],"funding_grant_id":["P20 GM139769","R35 GM146926","R56 AG056169","R35 GM146886","P51 OD011092","R01 AG056169","T15 LM007093","R01 HG002385","R01 MH120295","R35 GM151945","U24 HG007497","P01 AI152999","R35 GM142916","R01 HG007352","R35 GM133600","U24 HG010263","R35 GM133747","U41 HG007234","UH3 AG064706","R35 GM122550","R01 HG010329","R01 HG010169","R35 HG011332","R01 HG013017","U19 AG023122","R01 GM123312"],"pubmed_authors":["Zhao SA","Crawford J","Malukiewicz J","Son DR","Zhang S","Feschotte C","Torres-Gonzalez E","Zhang P","Lees W","Logsdon GA","Brannan E","Loh YHE","Sacco S","Lewis AP","Jeong H","Loftus M","Canzar S","Munson KM","Ryder OA","Guarracino A","Bankevich A","Montinaro F","Lin J","Potapova T","Engelbrecht E","Rivas-Gonzalez I","Schork NJ","Steiner C","Zhu Y","Yi SV","Hebbar P","Masterson P","Sasaki T","Schatz MC","Rhie A","Wei W","Kamali K","Thibaud-Nissen F","Meyer BS","McGrath B","Lowe CB","Diekhans M","Lee C","Hiller M","Koren S","Biddanda A","Pickett BD","de Gennaro L","Wertz J","Hickey G","Miga KH","Garrison E","Szpiech ZA","Balachandran P","Kellis M","Tassia MG","Pal K","Saha S","Huber CD","Phillippy AM","Sequeira AN","Carrel L","Loucks H","Han J","Lee Y","Watson CT","Pennell M","Pevzner PA","Roha JL","Haddad D","Paten B","Green RE","Ventura M","Antipov D","O'Neill RJ","Safonova Y","Brooks SY","McCoy RC","Gupta I","Houck ML","Solar SJ","Mangan RJ","Jarvis ED","Gilbert D","Yang M","Garcia GH","Storer JM","Li Q","Lenz TL","Ringeling FR","Trivedi M","Molloy E","Borchers M","Bouffard GG","McKinney S","Shanks C","Sudmant PH","Formenti G","Smeds L","Yoo D","Sweeten AP","Martinez JFI","Antonacci F","Kille B","Mao Y","Chan AP","Hoekzema K","Makova KD","Harris RS","Porubsky D","Konkel MK","Carbone L","Mohanty SK","Anez GM","Hartley GA","Zhang Z","Harvey WT","Zhang Y","Eichler EE","Luo Y","Ma J","Gerton JL","Beck CR"],"additional_accession":[]},"is_claimable":false,"name":"Complete sequencing of ape genomes.","description":"We present haplotype-resolved reference genomes and comparative analyses of six ape species, namely: chimpanzee, bonobo, gorilla, Bornean orangutan, Sumatran orangutan, and siamang. We achieve chromosome-level contiguity with unparalleled sequence accuracy (<1 error in 500,000 base pairs), completely sequencing 215 gapless chromosomes telomere-to-telomere. We resolve challenging regions, such as the major histocompatibility complex and immunoglobulin loci, providing more in-depth evolutionary insights. Comparative analyses, including human, allow us to investigate the evolution and diversity of regions previously uncharacterized or incompletely studied without bias from mapping to the human reference. This includes newly minted gene families within lineage-specific segmental duplications, ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Oct","modification":"2026-05-28T03:14:00.747Z","creation":"2025-04-04T01:57:33.288Z"},"accession":"S-EPMC11312596","cross_references":{"pubmed":["39131277"],"doi":["10.1101/2024.07.31.605654"]}}