{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["29(15)"],"submitter":["Benhabrou H"],"pubmed_abstract":["The pterocarpan fraction from aerial parts of <i>Bituminaria bituminosa</i> was investigated for both chemical characterization and biological evaluation. Chemical studies were in accordance with the literature data on <i>Bituminaria</i> genus resulting in the identification of typical 4,8-prenyl pterocarpans. Three new members, bituminarins A-C (<b>1</b>-<b>3</b>), were isolated along with main bitucarpin A (<b>4</b>), erybraedin C (<b>5</b>) and erybraedin D (<b>6</b>) already reported from this plant. Further, biological studies evidenced antiproliferative properties of the most abundant pterocarpans <b>4</b> and <b>5</b> on neuroblastoma SH-SY5Y cell line, in agreement with previously described antiproliferative activity of these compounds against cancer cell lines other than neuroblas"],"journal":["Molecules (Basel, Switzerland)"],"pagination":["3678"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11313871"],"repository":["biostudies-literature"],"pubmed_title":["Prenyl Pterocarpans from Algerian <i>Bituminaria bituminosa</i> and Their Effects on Neuroblastoma."],"pmcid":["PMC11313871"],"pubmed_authors":["Benhabrou H","Ciavatta ML","Nicois A","Ammar D","Bitam F","Gavagnin M","Carbone M","Cristino L"],"additional_accession":[]},"is_claimable":false,"name":"Prenyl Pterocarpans from Algerian <i>Bituminaria bituminosa</i> and Their Effects on Neuroblastoma.","description":"The pterocarpan fraction from aerial parts of <i>Bituminaria bituminosa</i> was investigated for both chemical characterization and biological evaluation. Chemical studies were in accordance with the literature data on <i>Bituminaria</i> genus resulting in the identification of typical 4,8-prenyl pterocarpans. Three new members, bituminarins A-C (<b>1</b>-<b>3</b>), were isolated along with main bitucarpin A (<b>4</b>), erybraedin C (<b>5</b>) and erybraedin D (<b>6</b>) already reported from this plant. Further, biological studies evidenced antiproliferative properties of the most abundant pterocarpans <b>4</b> and <b>5</b> on neuroblastoma SH-SY5Y cell line, in agreement with previously described antiproliferative activity of these compounds against cancer cell lines other than neuroblas","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-18T20:06:46.132Z","creation":"2025-04-07T07:55:20.845Z"},"accession":"S-EPMC11313871","cross_references":{"pubmed":["39125081"],"doi":["10.3390/molecules29153678"]}}