biostudies-literatureUnknown29(15)Benhabrou HThe pterocarpan fraction from aerial parts of <i>Bituminaria bituminosa</i> was investigated for both chemical characterization and biological evaluation. Chemical studies were in accordance with the literature data on <i>Bituminaria</i> genus resulting in the identification of typical 4,8-prenyl pterocarpans. Three new members, bituminarins A-C (<b>1</b>-<b>3</b>), were isolated along with main bitucarpin A (<b>4</b>), erybraedin C (<b>5</b>) and erybraedin D (<b>6</b>) already reported from this plant. Further, biological studies evidenced antiproliferative properties of the most abundant pterocarpans <b>4</b> and <b>5</b> on neuroblastoma SH-SY5Y cell line, in agreement with previously described antiproliferative activity of these compounds against cancer cell lines other than neuroblasMolecules (Basel, Switzerland)3678https://www.ebi.ac.uk/biostudies/studies/S-EPMC11313871biostudies-literaturePrenyl Pterocarpans from Algerian <i>Bituminaria bituminosa</i> and Their Effects on Neuroblastoma.PMC11313871Benhabrou HCiavatta MLNicois AAmmar DBitam FGavagnin MCarbone MCristino LfalsePrenyl Pterocarpans from Algerian <i>Bituminaria bituminosa</i> and Their Effects on Neuroblastoma.The pterocarpan fraction from aerial parts of <i>Bituminaria bituminosa</i> was investigated for both chemical characterization and biological evaluation. Chemical studies were in accordance with the literature data on <i>Bituminaria</i> genus resulting in the identification of typical 4,8-prenyl pterocarpans. Three new members, bituminarins A-C (<b>1</b>-<b>3</b>), were isolated along with main bitucarpin A (<b>4</b>), erybraedin C (<b>5</b>) and erybraedin D (<b>6</b>) already reported from this plant. Further, biological studies evidenced antiproliferative properties of the most abundant pterocarpans <b>4</b> and <b>5</b> on neuroblastoma SH-SY5Y cell line, in agreement with previously described antiproliferative activity of these compounds against cancer cell lines other than neuroblas2024-01-01T00:00:00Z2024 Aug2025-04-18T20:06:46.132Z2025-04-07T07:55:20.845ZS-EPMC113138713912508110.3390/molecules29153678