{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Feierman ER"],"funding":["NICHD NIH HHS","NIMH NIH HHS","NCI NIH HHS","NINDS NIH HHS","NIGMS NIH HHS"],"pagination":["2822-2837.e11"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11316635"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["84(15)"],"pubmed_abstract":["Histone proteins affect gene expression through multiple mechanisms, including through exchange with histone variants. Recent findings link histone variants to neurological disorders, yet few are well studied in the brain. Most notably, widely expressed variants of H2B remain elusive. We applied recently developed antibodies, biochemical assays, and sequencing approaches to reveal broad expression of the H2B variant H2BE and defined its role in regulating chromatin structure, neuronal transcription, and mouse behavior. We find that H2BE is enriched at promoters, and a single unique amino acid allows it to dramatically enhance chromatin accessibility. Further, we show that H2BE is critical for synaptic gene expression and long-term memory. Together, these data reveal a mechanism linking histone variants to chromatin accessibility, transcriptional regulation, neuronal function, and memory. This work further identifies a widely expressed H2B variant and uncovers a single histone amino acid with profound effects on genomic structure."],"journal":["Molecular cell"],"pubmed_title":["Histone variant H2BE enhances chromatin accessibility in neurons to promote synaptic gene expression and long-term memory."],"pmcid":["PMC11316635"],"funding_grant_id":["DP2 MH129985","F99 CA264420","P30 CA008748","F31 MH126576","T32 GM141949","T32 GM008216","K99 MH111836","R01 NS134755","U54 HD086984","R00 MH111836"],"pubmed_authors":["Lynch KT","Mehta SD","Louzon S","Qiu Q","Choi K","Prescott NA","Wu H","Feierman ER","Gao Q","David Y","Korb E","Biaco T","Palozola KC","Quaye CN","Fuccillo MV","Voss AJ"],"additional_accession":[]},"is_claimable":false,"name":"Histone variant H2BE enhances chromatin accessibility in neurons to promote synaptic gene expression and long-term memory.","description":"Histone proteins affect gene expression through multiple mechanisms, including through exchange with histone variants. Recent findings link histone variants to neurological disorders, yet few are well studied in the brain. Most notably, widely expressed variants of H2B remain elusive. We applied recently developed antibodies, biochemical assays, and sequencing approaches to reveal broad expression of the H2B variant H2BE and defined its role in regulating chromatin structure, neuronal transcription, and mouse behavior. We find that H2BE is enriched at promoters, and a single unique amino acid allows it to dramatically enhance chromatin accessibility. Further, we show that H2BE is critical for synaptic gene expression and long-term memory. Together, these data reveal a mechanism linking histone variants to chromatin accessibility, transcriptional regulation, neuronal function, and memory. This work further identifies a widely expressed H2B variant and uncovers a single histone amino acid with profound effects on genomic structure.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-04-12T19:30:20.702Z","creation":"2026-04-07T13:21:05.977Z"},"accession":"S-EPMC11316635","cross_references":{"pubmed":["39025074"],"doi":["10.1016/j.molcel.2024.06.025"]}}