{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kennelly SA"],"funding":["University of Minnesota","National Cancer Institute","NCI NIH HHS"],"pagination":["1334-1339"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11318099"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(8)"],"pubmed_abstract":["The antiviral enzyme viperin catalyzes the formation of 3'-deoxy-3',4'-didehydro-cytidine-5'-triphosphate (ddhCTP). ddhCTP is incorporated into viral genomes and terminates genomic replication to confer broad-spectrum antiviral effects. We have previously utilized phosphoramidate pronucleotide (ProTide) technology to enable metabolic production of ddhCTP in cells from an exogenously dosed 3'-deoxy-3',4'-didehydro-cytidine ProTide, which confers inhibitory activity against West Nile virus (WNV) and Zika virus (ZIKV). Herein, we synthesized 3'-deoxy-3',4'-didehydro-nucleosides containing all native nucleobases (thymine, uracil, adenine, guanine, and hypoxanthine), elaborated each to a ProTide, and measured their activity for controlling WNV and ZIKV infection. In comparison to the ddhC ProTi"],"journal":["ACS medicinal chemistry letters"],"pubmed_title":["Development of 3'-Deoxy-3',4'-didehydro-nucleoside Prodrug Inhibitors of West Nile and Zika Viruses."],"pmcid":["PMC11318099"],"funding_grant_id":["P30-CA77598","P30 CA077598","293501"],"pubmed_authors":["Sawyer JM","Payne AF","Ciota AT","Harki DA","Kennelly SA"],"additional_accession":[]},"is_claimable":false,"name":"Development of 3'-Deoxy-3',4'-didehydro-nucleoside Prodrug Inhibitors of West Nile and Zika Viruses.","description":"The antiviral enzyme viperin catalyzes the formation of 3'-deoxy-3',4'-didehydro-cytidine-5'-triphosphate (ddhCTP). ddhCTP is incorporated into viral genomes and terminates genomic replication to confer broad-spectrum antiviral effects. We have previously utilized phosphoramidate pronucleotide (ProTide) technology to enable metabolic production of ddhCTP in cells from an exogenously dosed 3'-deoxy-3',4'-didehydro-cytidine ProTide, which confers inhibitory activity against West Nile virus (WNV) and Zika virus (ZIKV). Herein, we synthesized 3'-deoxy-3',4'-didehydro-nucleosides containing all native nucleobases (thymine, uracil, adenine, guanine, and hypoxanthine), elaborated each to a ProTide, and measured their activity for controlling WNV and ZIKV infection. In comparison to the ddhC ProTi","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2026-04-12T19:24:28.025Z","creation":"2026-04-07T13:17:29.201Z"},"accession":"S-EPMC11318099","cross_references":{"pubmed":["39140046"],"doi":["10.1021/acsmedchemlett.4c00225"]}}