biostudies-literatureUnknown43(9)Lees EAWellcome Trust<h4>Background</h4>During autumn/winter 2022, UK pediatricians reported an unseasonal increase in invasive group A streptococcal infections; a striking proportion presenting with pneumonia with parapneumonic effusion.<h4>Methods</h4>Clinicians across the United Kingdom were requested to submit pseudonymized clinical data using a standardized report form for children (<16 years) admitted between September 30, 2022 and February 17, 2023, with microbiologically confirmed group A streptococcal pneumonia with parapneumonic effusion.<h4>Results</h4>From 185 cases submitted, the median patient age was 4.4 years, and 163 (88.1%) were previously healthy. Respiratory viral coinfection was detected on admission for 101/153 (66.0%) children using extended respiratory pathogen polymerase chain reactionThe Pediatric infectious disease journal841-850https://www.ebi.ac.uk/biostudies/studies/S-EPMC11319078biostudies-literatureEpidemiology and Management of Pediatric Group A Streptococcal Pneumonia With Parapneumonic Effusion: An Observational Study.PMC11319078Williams TCSinha AHaynes NFidler KBrampton RGordon SKoo SHoskyns LHatcher JBakar ABlomquist PAdesina AEveritt LCarveth Johnson TFitzgerald FWatson GPillai AFinlay JDixon GSpeirs LLyall HLees EAMarlow RDrysdale SPollock LHey ABernatoniene JMcMaster PLongbottom KWhittaker EOakley JLlano MLamagni TGroup A Streptococcal Disease ConsortiumDevesa PAlexander NHayes EJones CGarde AElghuwael IInwald DBamford AHull JIves AKavanagh SKirk NKent AKilpatrick CSang TCRutter MPike KRandle ESmith AMitting RWalsh LRiordan ALorenzetti GKuruvilla GBridge TKumar DKadambari SBowen SJVergnano SKuek SHormigo IMcShane TDBandi SBrugha RBycroft TFarah SfalseEpidemiology and Management of Pediatric Group A Streptococcal Pneumonia With Parapneumonic Effusion: An Observational Study.<h4>Background</h4>During autumn/winter 2022, UK pediatricians reported an unseasonal increase in invasive group A streptococcal infections; a striking proportion presenting with pneumonia with parapneumonic effusion.<h4>Methods</h4>Clinicians across the United Kingdom were requested to submit pseudonymized clinical data using a standardized report form for children (<16 years) admitted between September 30, 2022 and February 17, 2023, with microbiologically confirmed group A streptococcal pneumonia with parapneumonic effusion.<h4>Results</h4>From 185 cases submitted, the median patient age was 4.4 years, and 163 (88.1%) were previously healthy. Respiratory viral coinfection was detected on admission for 101/153 (66.0%) children using extended respiratory pathogen polymerase chain reaction2024-01-01T00:00:00Z2024 Sep2025-04-19T14:50:08.588Z2025-04-19T14:50:08.588ZS-EPMC113190783890003610.1097/INF.0000000000004418