{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["33(11)"],"submitter":["Jang SW"],"pubmed_abstract":["<i>Phlomoides umbrosa</i> Turczaninow (PU), a traditional Korean medicinal herb, exhibits osteogenic and anti-inflammatory effects. This research explored the effect of PU extracts on hyperimmune responses within the respiratory tract using lipopolysaccharide-stimulated RAW 264.7 cells and an ovalbumin-induced hyper-responsiveness model. The inflammatory cytokines, protein expression linked to airway inflammation, antioxidant enzyme activity, histopathological observation, and expectorant activity were measured. The results revealed that PU treatment led to a concentration-dependent reduction in Th2 cytokines and the expression of nuclear factor (NF)-κB, phosphatase-tensin homolog, mitogen-activated protein kinase (MAPK), and inducible nitric oxide synthase (iNOS). Simultaneously, antioxid"],"journal":["Food science and biotechnology"],"pagination":["2611-2621"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11319699"],"repository":["biostudies-literature"],"pubmed_title":["Extracts of <i>Phlomoides umbrosa</i> Turczaninow alleviate allergic airway inflammation in lipopolysaccharide-stimulated RAW 264.7 cells and ovalbumin-induced hyper-responsiveness mouse model."],"pmcid":["PMC11319699"],"pubmed_authors":["Lee JS","Lee YS","Kim JM","Jang SW","Jo HN","Lee DY","Park CS","Kim KW","Kim BM","Lee YW","Han YY"],"additional_accession":[]},"is_claimable":false,"name":"Extracts of <i>Phlomoides umbrosa</i> Turczaninow alleviate allergic airway inflammation in lipopolysaccharide-stimulated RAW 264.7 cells and ovalbumin-induced hyper-responsiveness mouse model.","description":"<i>Phlomoides umbrosa</i> Turczaninow (PU), a traditional Korean medicinal herb, exhibits osteogenic and anti-inflammatory effects. This research explored the effect of PU extracts on hyperimmune responses within the respiratory tract using lipopolysaccharide-stimulated RAW 264.7 cells and an ovalbumin-induced hyper-responsiveness model. The inflammatory cytokines, protein expression linked to airway inflammation, antioxidant enzyme activity, histopathological observation, and expectorant activity were measured. The results revealed that PU treatment led to a concentration-dependent reduction in Th2 cytokines and the expression of nuclear factor (NF)-κB, phosphatase-tensin homolog, mitogen-activated protein kinase (MAPK), and inducible nitric oxide synthase (iNOS). Simultaneously, antioxid","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-18T12:46:41.376Z","creation":"2025-04-06T22:07:14.711Z"},"accession":"S-EPMC11319699","cross_references":{"pubmed":["39144197"],"doi":["10.1007/s10068-024-01521-3"]}}