{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Chen J"],"funding":["National Natural Science Foundation of China"],"pagination":["106"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11320769"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["<h4>Background</h4>To explore the capability of diffusion-based virtual MR elastography (vMRE) in the preoperative prediction of recurrence in hepatocellular carcinoma (HCC) and to investigate the underlying relevant histopathological characteristics.<h4>Methods</h4>Between August 2015 and December 2016, patients underwent preoperative MRI examination with a dedicated DWI sequence (b-values: 200,1500 s/mm<sup>2</sup>) were recruited. The ADC values and diffusion-based virtual shear modulus (μ<sub>diff</sub>) of HCCs were calculated and MR morphological features were also analyzed. The Cox proportional hazards model was used to identify the risk factors associated with tumor recurrence. A preoperative radiologic model and postoperative model including pathological features were built to predict tumor recurrence after hepatectomy.<h4>Results</h4>A total of 87 patients with solitary surgically confirmed HCCs were included in this study. Thirty-five patients (40.2%) were found to have tumor recurrence after hepatectomy. The preoperative model included higher μ<sub>diff</sub> and corona enhancement, while the postoperative model included higher μ<sub>diff</sub>, microvascular invasion, and histologic tumor grade. These factors were identified as significant prognostic factors for recurrence-free survival (RFS) (all p < 0.05). The HCC patients with μ<sub>diff</sub> values > 2.325 kPa showed poorer 5-year RFS after hepatectomy than patients with μ<sub>diff</sub> values ≤ 2.325 kPa (p < 0.001). Moreover, the higher μ<sub>diff</sub> values was correlated with the expression of CK19 (3.95 ± 2.37 vs. 3.15 ± 1.77, p = 0.017) and high Ki-67 labeling index (4.22 ± 1.63 vs. 2.72 ± 2.12, p = 0.001).<h4>Conclusions</h4>The μ<sub>diff</sub> values related to the expression of CK19 and Ki-67 labeling index potentially predict RFS after hepatectomy in HCC patients."],"journal":["Cancer imaging : the official publication of the International Cancer Imaging Society"],"pubmed_title":["Diffusion-based virtual MR elastography for predicting recurrence of solitary hepatocellular carcinoma after hepatectomy."],"pmcid":["PMC11320769"],"funding_grant_id":["No. 82272078"],"pubmed_authors":["Rao S","Fu C","Chen J","Zeng M","Wang W","Sun W","Grimm R"],"additional_accession":[]},"is_claimable":false,"name":"Diffusion-based virtual MR elastography for predicting recurrence of solitary hepatocellular carcinoma after hepatectomy.","description":"<h4>Background</h4>To explore the capability of diffusion-based virtual MR elastography (vMRE) in the preoperative prediction of recurrence in hepatocellular carcinoma (HCC) and to investigate the underlying relevant histopathological characteristics.<h4>Methods</h4>Between August 2015 and December 2016, patients underwent preoperative MRI examination with a dedicated DWI sequence (b-values: 200,1500 s/mm<sup>2</sup>) were recruited. The ADC values and diffusion-based virtual shear modulus (μ<sub>diff</sub>) of HCCs were calculated and MR morphological features were also analyzed. The Cox proportional hazards model was used to identify the risk factors associated with tumor recurrence. A preoperative radiologic model and postoperative model including pathological features were built to predict tumor recurrence after hepatectomy.<h4>Results</h4>A total of 87 patients with solitary surgically confirmed HCCs were included in this study. Thirty-five patients (40.2%) were found to have tumor recurrence after hepatectomy. The preoperative model included higher μ<sub>diff</sub> and corona enhancement, while the postoperative model included higher μ<sub>diff</sub>, microvascular invasion, and histologic tumor grade. These factors were identified as significant prognostic factors for recurrence-free survival (RFS) (all p < 0.05). The HCC patients with μ<sub>diff</sub> values > 2.325 kPa showed poorer 5-year RFS after hepatectomy than patients with μ<sub>diff</sub> values ≤ 2.325 kPa (p < 0.001). Moreover, the higher μ<sub>diff</sub> values was correlated with the expression of CK19 (3.95 ± 2.37 vs. 3.15 ± 1.77, p = 0.017) and high Ki-67 labeling index (4.22 ± 1.63 vs. 2.72 ± 2.12, p = 0.001).<h4>Conclusions</h4>The μ<sub>diff</sub> values related to the expression of CK19 and Ki-67 labeling index potentially predict RFS after hepatectomy in HCC patients.","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2024-11-05T16:07:36.184Z","creation":"2024-11-05T16:07:36.184Z"},"accession":"S-EPMC11320769","cross_references":{"pubmed":["39138500"],"doi":["10.1186/s40644-024-00759-8"]}}