{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["29(4)"],"submitter":["Stroeder J"],"pubmed_abstract":["<h4>Objective</h4>To determine a conversion factor for use when switching from dexmedetomidine infusion to enteral clonidine in critically ill neonates.<h4>Methods</h4>This was an observational, retrospective review of conversions from dexmedetomidine to -clonidine, performed in a neonatal intensive care unit (NICU) between January 2020 and December 2021. Both initial conversion factors and those resulting after a 48-hour titration period were examined. Sedation and withdrawal scores were measured, and doses were titrated based on a standardized practice within the unit.<h4>Results</h4>A total of 43 dexmedetomidine to clonidine conversions were included. The median (IQR) dexmedetomidine dose prior to conversion was 17.4 (11.3-24.0) mcg/kg/day (0.7 mcg/kg/hr) and the median (IQR) enteral cl"],"journal":["The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG"],"pagination":["375-378"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11321815"],"repository":["biostudies-literature"],"pubmed_title":["Identification of a Conversion Factor for Dexmedetomidine to Clonidine Transitions."],"pmcid":["PMC11321815"],"pubmed_authors":["Stroeder J","Dersch-Mills D"],"additional_accession":[]},"is_claimable":false,"name":"Identification of a Conversion Factor for Dexmedetomidine to Clonidine Transitions.","description":"<h4>Objective</h4>To determine a conversion factor for use when switching from dexmedetomidine infusion to enteral clonidine in critically ill neonates.<h4>Methods</h4>This was an observational, retrospective review of conversions from dexmedetomidine to -clonidine, performed in a neonatal intensive care unit (NICU) between January 2020 and December 2021. Both initial conversion factors and those resulting after a 48-hour titration period were examined. Sedation and withdrawal scores were measured, and doses were titrated based on a standardized practice within the unit.<h4>Results</h4>A total of 43 dexmedetomidine to clonidine conversions were included. The median (IQR) dexmedetomidine dose prior to conversion was 17.4 (11.3-24.0) mcg/kg/day (0.7 mcg/kg/hr) and the median (IQR) enteral cl","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-04T02:20:49Z","creation":"2024-11-05T16:00:46.446Z"},"accession":"S-EPMC11321815","cross_references":{"pubmed":["39144393"],"doi":["10.5863/1551-6776-29.4.375"]}}