biostudies-literatureUnknown29(4)Stroeder J<h4>Objective</h4>To determine a conversion factor for use when switching from dexmedetomidine infusion to enteral clonidine in critically ill neonates.<h4>Methods</h4>This was an observational, retrospective review of conversions from dexmedetomidine to -clonidine, performed in a neonatal intensive care unit (NICU) between January 2020 and December 2021. Both initial conversion factors and those resulting after a 48-hour titration period were examined. Sedation and withdrawal scores were measured, and doses were titrated based on a standardized practice within the unit.<h4>Results</h4>A total of 43 dexmedetomidine to clonidine conversions were included. The median (IQR) dexmedetomidine dose prior to conversion was 17.4 (11.3-24.0) mcg/kg/day (0.7 mcg/kg/hr) and the median (IQR) enteral clThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG375-378https://www.ebi.ac.uk/biostudies/studies/S-EPMC11321815biostudies-literatureIdentification of a Conversion Factor for Dexmedetomidine to Clonidine Transitions.PMC11321815Stroeder JDersch-Mills DfalseIdentification of a Conversion Factor for Dexmedetomidine to Clonidine Transitions.<h4>Objective</h4>To determine a conversion factor for use when switching from dexmedetomidine infusion to enteral clonidine in critically ill neonates.<h4>Methods</h4>This was an observational, retrospective review of conversions from dexmedetomidine to -clonidine, performed in a neonatal intensive care unit (NICU) between January 2020 and December 2021. Both initial conversion factors and those resulting after a 48-hour titration period were examined. Sedation and withdrawal scores were measured, and doses were titrated based on a standardized practice within the unit.<h4>Results</h4>A total of 43 dexmedetomidine to clonidine conversions were included. The median (IQR) dexmedetomidine dose prior to conversion was 17.4 (11.3-24.0) mcg/kg/day (0.7 mcg/kg/hr) and the median (IQR) enteral cl2024-01-01T00:00:00Z2024 Aug2025-04-04T02:20:49Z2024-11-05T16:00:46.446ZS-EPMC113218153914439310.5863/1551-6776-29.4.375