{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Naderi J"],"funding":["Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie","Bundesministerium für Bildung, Wissenschaft, Forschung und Technologie (Federal Ministry for Education, Science, Research and Technology)","Deutsche Forschungsgemeinschaft","Deutsche Forschungsgemeinschaft (German Research Foundation)","Consell Català de Recerca i Innovació (Catalan Council for Research and Innovation)","Consell Català de Recerca i Innovació"],"pagination":["1309-1321"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11321997"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(8)"],"pubmed_abstract":["Transcription factors (TFs) control specificity and activity of gene transcription, but whether a relationship between these two features exists is unclear. Here we provide evidence for an evolutionary trade-off between the activity and specificity in human TFs encoded as submaximal dispersion of aromatic residues in their intrinsically disordered protein regions. We identified approximately 500 human TFs that encode short periodic blocks of aromatic residues in their intrinsically disordered regions, resembling imperfect prion-like sequences. Mutation of periodic aromatic residues reduced transcriptional activity, whereas increasing the aromatic dispersion of multiple human TFs enhanced transcriptional activity and reprogramming efficiency, promoted liquid-liquid phase separation in vitro"],"journal":["Nature cell biology"],"pubmed_title":["An activity-specificity trade-off encoded in human transcription factors."],"pmcid":["PMC11321997"],"funding_grant_id":["FKZ 031L0169A","XXX","HN 4/3-1"],"pubmed_authors":["Rossi F","Buschow R","Magalhaes AP","Kibar G","Vingron M","Alcoverro-Bertran M","Naderi J","Zhang Y","Mackowiak SD","Graf T","Christou-Kent M","Stik G","Hnisz D","Wieler HM"],"additional_accession":[]},"is_claimable":false,"name":"An activity-specificity trade-off encoded in human transcription factors.","description":"Transcription factors (TFs) control specificity and activity of gene transcription, but whether a relationship between these two features exists is unclear. Here we provide evidence for an evolutionary trade-off between the activity and specificity in human TFs encoded as submaximal dispersion of aromatic residues in their intrinsically disordered protein regions. We identified approximately 500 human TFs that encode short periodic blocks of aromatic residues in their intrinsically disordered regions, resembling imperfect prion-like sequences. Mutation of periodic aromatic residues reduced transcriptional activity, whereas increasing the aromatic dispersion of multiple human TFs enhanced transcriptional activity and reprogramming efficiency, promoted liquid-liquid phase separation in vitro","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-05-18T12:14:05.138Z","creation":"2025-04-05T10:09:41.408Z"},"accession":"S-EPMC11321997","cross_references":{"pubmed":["38969762"],"doi":["10.1038/s41556-024-01411-0"]}}