{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(32)"],"submitter":["Zhang H"],"pubmed_abstract":["Even though catalytic asymmetric bifunctionalization of allenes has been extensively studied, almost all of the reported examples have been achieved in a two-component manner. In this study, we report a highly efficient asymmetric bifunctionalization of allenes with iodohydrocarbons and NH<sub>2</sub>-unprotected amino acid esters. The adopted chiral aldehyde/palladium combined catalytic system precisely governs the chemoselectivity, regioselectivity, and stereoselectivity of this three-component reaction. A wide range of substituted aryl iodides, allenes and amino acid esters can well participate in this reaction and deliver structurally diverse α,α-disubstituted α-amino acid esters with excellent experimental outcomes. One of the resulting products is utilized for the total synthesis of "],"journal":["Chemical science"],"pagination":["12983-12988"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11322975"],"repository":["biostudies-literature"],"pubmed_title":["Asymmetric bifunctionalization of allenes with aryl iodides and amino acids enabled by chiral aldehyde/palladium combined catalysis."],"pmcid":["PMC11322975"],"pubmed_authors":["Lu ZX","Cai T","Zhang H","Liu JL","Wu ZL","Wang YY","Guo QX","Wen W"],"additional_accession":[]},"is_claimable":false,"name":"Asymmetric bifunctionalization of allenes with aryl iodides and amino acids enabled by chiral aldehyde/palladium combined catalysis.","description":"Even though catalytic asymmetric bifunctionalization of allenes has been extensively studied, almost all of the reported examples have been achieved in a two-component manner. In this study, we report a highly efficient asymmetric bifunctionalization of allenes with iodohydrocarbons and NH<sub>2</sub>-unprotected amino acid esters. The adopted chiral aldehyde/palladium combined catalytic system precisely governs the chemoselectivity, regioselectivity, and stereoselectivity of this three-component reaction. A wide range of substituted aryl iodides, allenes and amino acid esters can well participate in this reaction and deliver structurally diverse α,α-disubstituted α-amino acid esters with excellent experimental outcomes. One of the resulting products is utilized for the total synthesis of ","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-19T14:50:57.03Z","creation":"2025-04-19T14:50:57.03Z"},"accession":"S-EPMC11322975","cross_references":{"pubmed":["39148795"],"doi":["10.1039/d4sc03398a"]}}