{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Balderston NL"],"funding":["National Alliance for Research on Schizophrenia and Depression","NIMH NIH HHS","NIH"],"pagination":["16-25"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11323191"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["165"],"pubmed_abstract":["<h4>Objective</h4>Transcranial magnetic stimulation (TMS) can efficiently and robustly modulate synaptic plasticity, but little is known about how TMS affects functional connectivity (rs-fMRI). Accordingly, this project characterized TMS-induced rsFC changes in depressed patients who received 3 days of left prefrontal intermittent theta burst stimulation (iTBS).<h4>Methods</h4>rs-fMRI was collected from 16 subjects before and after iTBS. Correlation matrices were constructed from the cleaned rs-fMRI data. Electric-field models were conducted and used to predict pre-post changes in rs-fMRI. Site by orientation heatmaps were created for vectors centered on the stimulation site and a control site (contralateral motor cortex).<h4>Results</h4>For the stimulation site, there was a clear relation"],"journal":["Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology"],"pubmed_title":["Neuromodulatory transcranial magnetic stimulation (TMS) changes functional connectivity proportional to the electric-field induced by the TMS pulse."],"pmcid":["PMC11323191"],"funding_grant_id":["R01 MH111886","U01 MH109991","K01 MH121777"],"pubmed_authors":["Figueroa-Gonzalez A","Sheline YI","Long H","Duprat RJ","Scully M","Deluisi JA","Balderston NL","Oathes DJ","Teferi M"],"additional_accession":[]},"is_claimable":false,"name":"Neuromodulatory transcranial magnetic stimulation (TMS) changes functional connectivity proportional to the electric-field induced by the TMS pulse.","description":"<h4>Objective</h4>Transcranial magnetic stimulation (TMS) can efficiently and robustly modulate synaptic plasticity, but little is known about how TMS affects functional connectivity (rs-fMRI). Accordingly, this project characterized TMS-induced rsFC changes in depressed patients who received 3 days of left prefrontal intermittent theta burst stimulation (iTBS).<h4>Methods</h4>rs-fMRI was collected from 16 subjects before and after iTBS. Correlation matrices were constructed from the cleaned rs-fMRI data. Electric-field models were conducted and used to predict pre-post changes in rs-fMRI. Site by orientation heatmaps were created for vectors centered on the stimulation site and a control site (contralateral motor cortex).<h4>Results</h4>For the stimulation site, there was a clear relation","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Sep","modification":"2026-05-29T06:54:56.663Z","creation":"2026-04-08T03:49:29.022Z"},"accession":"S-EPMC11323191","cross_references":{"pubmed":["38945031"],"doi":["10.1016/j.clinph.2024.06.007"]}}