biostudies-literatureBalderston NLNational Alliance for Research on Schizophrenia and DepressionNIMH NIH HHSNIH16-25https://www.ebi.ac.uk/biostudies/studies/S-EPMC11323191biostudies-literatureUnknown165<h4>Objective</h4>Transcranial magnetic stimulation (TMS) can efficiently and robustly modulate synaptic plasticity, but little is known about how TMS affects functional connectivity (rs-fMRI). Accordingly, this project characterized TMS-induced rsFC changes in depressed patients who received 3 days of left prefrontal intermittent theta burst stimulation (iTBS).<h4>Methods</h4>rs-fMRI was collected from 16 subjects before and after iTBS. Correlation matrices were constructed from the cleaned rs-fMRI data. Electric-field models were conducted and used to predict pre-post changes in rs-fMRI. Site by orientation heatmaps were created for vectors centered on the stimulation site and a control site (contralateral motor cortex).<h4>Results</h4>For the stimulation site, there was a clear relationClinical neurophysiology : official journal of the International Federation of Clinical NeurophysiologyNeuromodulatory transcranial magnetic stimulation (TMS) changes functional connectivity proportional to the electric-field induced by the TMS pulse.PMC11323191R01 MH111886U01 MH109991K01 MH121777Figueroa-Gonzalez ASheline YILong HDuprat RJScully MDeluisi JABalderston NLOathes DJTeferi MfalseNeuromodulatory transcranial magnetic stimulation (TMS) changes functional connectivity proportional to the electric-field induced by the TMS pulse.<h4>Objective</h4>Transcranial magnetic stimulation (TMS) can efficiently and robustly modulate synaptic plasticity, but little is known about how TMS affects functional connectivity (rs-fMRI). Accordingly, this project characterized TMS-induced rsFC changes in depressed patients who received 3 days of left prefrontal intermittent theta burst stimulation (iTBS).<h4>Methods</h4>rs-fMRI was collected from 16 subjects before and after iTBS. Correlation matrices were constructed from the cleaned rs-fMRI data. Electric-field models were conducted and used to predict pre-post changes in rs-fMRI. Site by orientation heatmaps were created for vectors centered on the stimulation site and a control site (contralateral motor cortex).<h4>Results</h4>For the stimulation site, there was a clear relation2024-01-01T00:00:00Z2024 Sep2026-05-29T06:54:56.663Z2026-04-08T03:49:29.022ZS-EPMC113231913894503110.1016/j.clinph.2024.06.007