{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Batliner M"],"funding":["Deutsche Forschungsgemeinschaft (DFG)","Deutsche Forschungsgemeinschaft"],"pagination":["e0073224"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC11323541"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(8)"],"pubmed_abstract":["<i>Candida albicans,</i> an opportunistic fungal pathogen, produces the quorum-sensing molecule farnesol, which we have shown alters the transcriptional response and phenotype of human monocyte-derived dendritic cells (DCs), including their cytokine secretion and ability to prime T cells. This is partially dependent on the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ), which has numerous ligands, including the sphingolipid metabolite sphingosine 1-phosphate. Sphingolipids are a vital component of membranes that affect membrane protein arrangement and phagocytosis of <i>C. albicans</i> by DCs. Thus, we quantified sphingolipid metabolites in monocytes differentiating into DCs by High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Farneso"],"journal":["mBio"],"pubmed_title":["The <i>Candida albicans</i> quorum-sensing molecule farnesol alters sphingolipid metabolism in human monocyte-derived dendritic cells."],"pmcid":["PMC11323541"],"funding_grant_id":["417857878","492620490","210879364"],"pubmed_authors":["Riedel A","Batliner M","Schempp R","Fekete A","Kohler T","Wigger D","Schumacher F","Fohmann I","Kurzai O","Prell A","Vaeth M","Kleuser B","Vivas W","Nieuwenhuizen NE"],"additional_accession":[]},"is_claimable":false,"name":"The <i>Candida albicans</i> quorum-sensing molecule farnesol alters sphingolipid metabolism in human monocyte-derived dendritic cells.","description":"<i>Candida albicans,</i> an opportunistic fungal pathogen, produces the quorum-sensing molecule farnesol, which we have shown alters the transcriptional response and phenotype of human monocyte-derived dendritic cells (DCs), including their cytokine secretion and ability to prime T cells. This is partially dependent on the nuclear receptor peroxisome proliferator-activated receptor gamma (PPAR-γ), which has numerous ligands, including the sphingolipid metabolite sphingosine 1-phosphate. Sphingolipids are a vital component of membranes that affect membrane protein arrangement and phagocytosis of <i>C. albicans</i> by DCs. Thus, we quantified sphingolipid metabolites in monocytes differentiating into DCs by High-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Farneso","dates":{"release":"2024-01-01T00:00:00Z","publication":"2024 Aug","modification":"2025-04-19T20:39:22.825Z","creation":"2025-04-19T20:39:22.825Z"},"accession":"S-EPMC11323541","cross_references":{"pubmed":["38953353"],"doi":["10.1128/mbio.00732-24"]}}